Sha Lei, Cai Meng-Yao, Feng Min, Dong Chang
Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Front Oncol. 2025 Aug 14;15:1626336. doi: 10.3389/fonc.2025.1626336. eCollection 2025.
Primary pulmonary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) localized in the trachea and bronchus is rare and diagnostically challenging due to nonspecific clinical and radiological features.
We present two cases of primary endobronchial MALT lymphoma incidentally diagnosed via bronchoscopy. We assessed the characteristic bronchoscopic finding of endobronchial MALT lymphoma, radiological examinations and overall treatment strategies.
This study highlights the importance of considering endobronchial MALT lymphoma as a potential diagnosis. A thorough bronchoscopic evaluation of the central airways, along with appropriate biopsy of suspicious lesions, is crucial. Endobronchial MALT lymphoma should be suspected when targeting multiple widely stalked and smooth submucosal nodules or protrusions, mainly located in the central airways.
局限于气管和支气管的原发性肺黏膜相关淋巴组织边缘区淋巴瘤(MALT淋巴瘤)罕见,因其临床和放射学特征不具特异性,诊断具有挑战性。
我们报告两例经支气管镜偶然诊断出的原发性支气管内MALT淋巴瘤病例。我们评估了支气管内MALT淋巴瘤的特征性支气管镜表现、放射学检查及整体治疗策略。
本研究强调了将支气管内MALT淋巴瘤视为一种潜在诊断的重要性。对中央气道进行全面的支气管镜评估,并对可疑病变进行适当活检至关重要。当发现多个主要位于中央气道的、有广泛蒂且表面光滑的黏膜下结节或隆起时,应怀疑支气管内MALT淋巴瘤。