Chen Shiyou, Ding Tao, Wang Jie, Liang Xiaofang, Wang Hao, Wang Junjun, Xue Min
National Aquafeed Safety Assessment Center, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Anim Nutr. 2025 Jul 5;22:291-310. doi: 10.1016/j.aninu.2025.03.017. eCollection 2025 Sep.
Bioactive peptides (BAPs), typically comprising two to 20 amino acids, are widely acknowledged for their distinctive biological functions. They can be broadly classified as endogenous or exogenous peptides. Integrating BAPs into feed is now deemed an efficacious nutritional strategy to enhance the resilience of farmed aquatic species against stress-induced damage and pathogen infections. Moreover, dietary BAPs have exhibited significantly favorable effects on fish and shrimp's feed utilization and growth performance. The present review comprehensively explores the extensive research on the diverse applications of BAPs in aquaculture, explicitly focusing on recent advances in utilizing antioxidative, antimicrobial, antiviral, anti-inflammatory and immunomodulatory peptides. Additionally, the study incorporates several common dipeptides and tripeptides to address the challenges associated with inefficient absorption, high production costs, and the inherent instability of amino acid monomers. Furthermore, the review explores the methods for obtaining BAPs through enzymatic hydrolysis technology, highlighting key challenges that require attention in aquatic research. This review is expected to encourage further investigation in the related fields.
生物活性肽（BAPs）通常由2至20个氨基酸组成，因其独特的生物学功能而被广泛认可。它们可大致分为内源性或外源性肽。将BAPs整合到饲料中，现在被认为是一种有效的营养策略，可增强养殖水产动物对压力诱导损伤和病原体感染的抵抗力。此外，日粮中的BAPs对鱼虾的饲料利用率和生长性能已显示出显著的有利影响。本综述全面探讨了BAPs在水产养殖中各种应用的广泛研究，特别关注利用抗氧化、抗菌、抗病毒、抗炎和免疫调节肽方面的最新进展。此外，该研究纳入了几种常见的二肽和三肽，以应对与吸收效率低、生产成本高以及氨基酸单体固有不稳定性相关的挑战。此外，本综述探讨了通过酶解技术获得BAPs的方法，强调了水产研究中需要关注的关键挑战。本综述有望鼓励在相关领域进行进一步研究。
