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PAI-1 and CHRNA1-A new molecular axis and therapeutic target in primary focal hyperhidrosis.

作者信息

Hoareau Marie, Zhang Rong-Mo

机构信息

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, 300 George Street, New Haven, CT 06511, USA.

Yale Stem Cell Center, 10 Amistad Street, New Haven, CT 06511, USA.

出版信息

Mol Ther Nucleic Acids. 2025 Aug 15;36(3):102664. doi: 10.1016/j.omtn.2025.102664. eCollection 2025 Sep 9.

DOI:10.1016/j.omtn.2025.102664
PMID:40896592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12391439/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/12391439/c3424a84951b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/12391439/c3424a84951b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0df0/12391439/c3424a84951b/gr1.jpg

相似文献

1
PAI-1 and CHRNA1-A new molecular axis and therapeutic target in primary focal hyperhidrosis.纤溶酶原激活物抑制剂-1与α1型烟碱乙酰胆碱受体α1亚基——原发性局灶性多汗症中的一条新分子轴及治疗靶点
Mol Ther Nucleic Acids. 2025 Aug 15;36(3):102664. doi: 10.1016/j.omtn.2025.102664. eCollection 2025 Sep 9.
2
PAI1 regulating CHRNA1 contributes to primary focal hyperhidrosis: Clinical and experimental studies.PAI1调控CHRNA1导致原发性局灶性多汗症：临床与实验研究
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3
PAI1 inhibits the pathogenesis of primary focal hyperhidrosis by targeting CHRNA1.PAI1 通过靶向 CHRNA1 抑制原发性局限性多汗症的发病机制。
Orphanet J Rare Dis. 2023 Jul 21;18(1):205. doi: 10.1186/s13023-023-02808-0.
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CHRNA1 promotes the pathogenesis of primary focal hyperhidrosis.CHRNA1 促进原发性局限性多汗症的发病机制。
Mol Cell Neurosci. 2021 Mar;111:103598. doi: 10.1016/j.mcn.2021.103598. Epub 2021 Jan 19.
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Antagonist of Chrna1 prevents the pathogenesis of primary focal hyperhidrosis.Chrna1 拮抗剂可预防原发性局限性多汗症的发病机制。
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本文引用的文献

1
PAI1 regulating CHRNA1 contributes to primary focal hyperhidrosis: Clinical and experimental studies.PAI1调控CHRNA1导致原发性局灶性多汗症：临床与实验研究
Mol Ther Nucleic Acids. 2025 May 16;36(2):102566. doi: 10.1016/j.omtn.2025.102566. eCollection 2025 Jun 10.
2
PAI1 inhibits the pathogenesis of primary focal hyperhidrosis by targeting CHRNA1.PAI1 通过靶向 CHRNA1 抑制原发性局限性多汗症的发病机制。
Orphanet J Rare Dis. 2023 Jul 21;18(1):205. doi: 10.1186/s13023-023-02808-0.
3
Hyperhidrosis: A Central Nervous Dysfunction of Sweat Secretion.
多汗症：一种汗液分泌的中枢神经功能障碍。
Dermatol Ther (Heidelb). 2023 Feb;13(2):453-463. doi: 10.1007/s13555-022-00885-w. Epub 2023 Jan 10.
4
Genome-wide linkage analysis of families with primary hyperhidrosis.原发性多汗症家族的全基因组连锁分析。
PLoS One. 2020 Dec 30;15(12):e0244565. doi: 10.1371/journal.pone.0244565. eCollection 2020.
5
Physiology of sweat gland function: The roles of sweating and sweat composition in human health.汗腺功能的生理学：出汗及汗液成分在人类健康中的作用。
Temperature (Austin). 2019 Jul 17;6(3):211-259. doi: 10.1080/23328940.2019.1632145. eCollection 2019.
6
Three-dimensional cell shapes and arrangements in human sweat glands as revealed by whole-mount immunostaining.通过整装免疫染色揭示的人体汗腺中的三维细胞形状和排列
PLoS One. 2017 Jun 21;12(6):e0178709. doi: 10.1371/journal.pone.0178709. eCollection 2017.
7
The nature and biology of basement membranes.基底膜的性质与生物学特性。
Matrix Biol. 2017 Jan;57-58:1-11. doi: 10.1016/j.matbio.2016.12.009. Epub 2016 Dec 28.
8
Eccrine sweat gland development and sweat secretion.外分泌汗腺的发育与汗液分泌。
Exp Dermatol. 2015 Sep;24(9):644-50. doi: 10.1111/exd.12773. Epub 2015 Jul 14.
9
PAI-1 in tissue fibrosis.组织纤维化中的 PAI-1。
J Cell Physiol. 2012 Feb;227(2):493-507. doi: 10.1002/jcp.22783.
10
Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk.纤溶酶原激活物抑制剂-1、炎症、肥胖、胰岛素抵抗与血管风险
J Thromb Haemost. 2003 Jul;1(7):1575-9. doi: 10.1046/j.1538-7836.2003.00279.x.