Shao Zhengqi, Wang Jian, Wang BaiChuan, Hu HongZhi
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Oncology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Front Surg. 2025 Aug 14;12:1582444. doi: 10.3389/fsurg.2025.1582444. eCollection 2025.
Epithelioid hemangioendothelioma (EHE) is a rare and locally aggressive tumour of vascular endothelial origin, with an estimated prevalence of less than 1 in a million. EHE can arise in any part of the body, most commonly in the liver, lungs, and skeleton, while occurrence in the blood vessels of the extremities is rare. This article reports a rare case of primary epithelioid hemangioendothelioma (EHE) of the right femoral artery. The patient was initially misdiagnosed with lower limb arterial occlusion and treated with stenting and other therapies; however, symptoms recurred, and the diagnosis of EHE was confirmed by pathological biopsy. EHE is very rare and accounts for approximately 1% of all vascular tumours. Based on pathological findings- CD31(+), CD34(-), CAMTA(+)-our patient was diagnosed with WWTR1-CAMTA1 fusion EHE.Treatment of EHE is mainly surgical. In our case, the patient underwent resection of the lesion area and the surrounding soft tissue mass, followed by a reconstruction using a left saphenous vein graft.
上皮样血管内皮瘤（EHE）是一种罕见的、具有局部侵袭性的血管内皮源性肿瘤，估计患病率低于百万分之一。EHE可发生于身体的任何部位，最常见于肝脏、肺和骨骼，而发生于四肢血管的情况罕见。本文报道了一例右侧股动脉原发性上皮样血管内皮瘤（EHE）的罕见病例。患者最初被误诊为下肢动脉闭塞，并接受了支架置入及其他治疗；然而，症状复发，经病理活检确诊为EHE。EHE非常罕见，约占所有血管肿瘤的1%。根据病理结果——CD31（+）、CD34（-）、CAMTA（+）——我们的患者被诊断为WWTR1-CAMTA1融合型EHE。EHE的治疗主要是手术治疗。在我们的病例中，患者接受了病变区域及周围软组织肿块的切除，随后使用左大隐静脉移植进行重建。
