Mamaeva G G, Serov V V, Spesivtseva V G, Mukhin N A, Varshavskiĭ V A
Ter Arkh. 1985;57(12):12-6.
The clinicofunctional characteristics of the kidneys were estimated, biopsy of the kidney and skin with an immunohistochemical study was performed and some immunity values considered in 17 patients with type I diabetes mellitus. The study was performed with respect to the degree of expression of the clinical signs of nephropathy including the preclinical stage, too. Three types of morphological changes in the kidney and skin were singled out. Initial tubuloglomerular disorders occurred at the preclinical stage of nephroangiopathy. The nature of changes in the skin coincided mostly with changes in the kidney lagging behind in some cases. The results confirmed the leading role of metabolic derangements in the genesis of microangiopathies and a necessity of a good compensation of diabetes for its prevention. The immunohistochemical and immunological findings did not make it possible to exclude the immune mechanisms in the development of diabetic nephroangiopathy.
对17例I型糖尿病患者的肾脏临床功能特征进行了评估，进行了肾脏和皮肤活检及免疫组化研究，并考虑了一些免疫指标。该研究针对包括临床前期在内的肾病临床症状的表达程度进行。在肾脏和皮肤中发现了三种形态学变化。肾小管-肾小球的初始紊乱发生在肾血管病的临床前期。皮肤变化的性质大多与肾脏变化一致，在某些情况下滞后。结果证实了代谢紊乱在微血管病发生中的主导作用以及良好控制糖尿病以预防其发生的必要性。免疫组化和免疫学结果无法排除免疫机制在糖尿病性肾血管病发展中的作用。
