Shapoval Vladyslav, Evrard Perrine, Sibille François-Xavier, López-Toribio María, Dalleur Olivia, Aubert Carole E, Bolt Lucy, Tsoutsi Vagioula, Ntafouli Maria, Maldonado Laura Fernández, Miralles Ramon, Wichniak Adam, Gustavsson Katarzyna, Wyller Torgeir Bruun, Callegari Enrico, Grimshaw Jeremy M, Presseau Justin, Henrard Séverine, Spinewine Anne
Clinical Pharmacy and Pharmacoepidemiology Research Group, Louvain Drug Research Institute, UCLouvain, Brussels, Belgium.
Department of Geriatric Medicine, CHU UCL Namur, Yvoir, Belgium.
Basic Clin Pharmacol Toxicol. 2025 Oct;137(4):e70100. doi: 10.1111/bcpt.70100.
Although physicians are primarily responsible for Benzodiazepine Receptor Agonist (BZRA) deprescribing, nonphysician healthcare professionals (HCPs) can support deprescribing. This study explored barriers to and enablers of BZRA deprescribing among nonphysician HCPs. We surveyed 258 HCPs (63.2% nurses) working in hospital settings across six European countries using a questionnaire based on the Theoretical Domain Framework (TDF). Logistic regression assessed associations between TDF domains and both intentions to support and routine engagement in BZRA deprescribing. Major barriers (TDF items with mean < 3) were found in the goals (competing priorities), environmental context and resources (time and staff lack) and social influences (patient reluctance) domains. Five TDF domains were associated with a stronger intention to support deprescribing: social/professional role and identity (OR, 3.08; 95% CI, 1.77-5.46); beliefs about consequences (OR, 1.91; 95% CI, 1.07-3.34); memory, attention and decision processing (OR, 1.80; 95% CI, 1.16-2.82); intention to promote alternatives (OR, 1.63; 95% CI, 1.07-2.49); and reinforcement (OR, 1.57; 95% CI, 1.08-2.29). Knowledge was the only domain associated with routine BZRA deprescribing support (OR, 1.16; 95% CI, 1.06-1.27). Different categories of HCPs face similar major barriers, but barriers vary across HCP categories and countries. Context-specific, targeted interventions may enhance support for BZRA deprescribing.
虽然医生主要负责苯二氮䓬受体激动剂(BZRA)的减药工作,但非医生医疗保健专业人员(HCPs)也可以提供支持。本研究探讨了非医生HCPs在BZRA减药方面的障碍和促进因素。我们使用基于理论领域框架(TDF)的问卷,对六个欧洲国家医院环境中的258名HCPs(63.2%为护士)进行了调查。逻辑回归评估了TDF领域与支持BZRA减药的意图以及日常参与之间的关联。在目标(相互竞争的优先事项)、环境背景和资源(时间和人员短缺)以及社会影响(患者不情愿)领域发现了主要障碍(TDF项目均值<3)。五个TDF领域与更强的支持减药意图相关:社会/专业角色和身份(OR,3.08;95%CI,1.77 - 5.46);对后果的信念(OR,1.91;95%CI,1.07 - 3.34);记忆、注意力和决策过程(OR,1.80;95%CI,1.16 - 2.82);推广替代方案的意图(OR,1.63;95%CI,1.07 - 2.49);以及强化(OR,1.57;95%CI,1.08 - 2.29)。知识是与日常BZRA减药支持相关的唯一领域(OR,1.16;95%CI,1.06 - 1.27)。不同类别的HCPs面临类似的主要障碍,但障碍因HCP类别和国家而异。针对具体情况的有针对性干预措施可能会加强对BZRA减药的支持。