Pawlik Olga, Cowan Timothy, Miller Andrew
Department of Dermatology, The Canberra Hospital, Canberra Health Services, ACT, Canberra, Australia.
Australian National University, School of Medicine and Psychology, ACT, Canberra, Australia.
Australas J Dermatol. 2025 Sep 2. doi: 10.1111/ajd.14577.
Generalised Bullous Fixed Drug Eruption (GBFDE) is a subtype of Fixed Drug Eruption (FDE) characterised by the development of generalised blisters on the background of dusky macules. There is no gold standard treatment, but the condition is conventionally managed with supportive care, topical and oral steroids and occasionally ciclosporin. We describe the case of a 75-year-old female with GBFDE, who demonstrated a rapid halt in disease progression and re-epithelialisation following a single dose of etanercept. This case highlights the potential role of etanercept in the management of GBFDE.
泛发性大疱性固定性药疹（GBFDE）是固定性药疹（FDE）的一种亚型，其特征是在暗红斑的基础上出现泛发性水疱。目前尚无金标准治疗方法，但传统上该病采用支持性护理、局部和口服类固醇药物治疗，偶尔也会使用环孢素。我们报告了一例75岁患有GBFDE的女性病例，该患者在单次注射依那西普后疾病进展迅速停止且重新上皮化。该病例突出了依那西普在GBFDE治疗中的潜在作用。
