系统性自身炎症性疾病患者与健康对照之间多功能性的基线单细胞差异
Baseline Single-Cell Differences in Polyfunctionality Between Systemic Autoinflammatory Diseases Patients and Healthy Controls.
作者信息
Linder Aline, Diab Farah, de Pontual Loïc, Giurgea Irina, Eyer Klaus
机构信息
Laboratory For Functional Immune Repertoire Analysis, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.
Sorbonne Université, Inserm, Maladies génétiques d'expression pédiatrique, Paris, France.
出版信息
Eur J Immunol. 2025 Sep;55(9):e70047. doi: 10.1002/eji.70047.
Dysregulated cytokine secretion and signaling underlie systemic autoinflammatory diseases (SAIDs). Here, we characterized immune dysregulation in SAID patients by profiling cytokine secretion at the single-cell level, establishing measurements for secretion dynamics and cellular polyfunctionality, compared with healthy controls, revealing natural variability within immune responses between donors.
细胞因子分泌和信号传导失调是系统性自身炎症性疾病（SAIDs）的基础。在此，我们通过在单细胞水平上分析细胞因子分泌、建立分泌动力学和细胞多功能性的测量方法，对SAID患者的免疫失调进行了特征描述，并与健康对照进行比较，揭示了供体之间免疫反应的自然变异性。
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