Watanabe Tomoko, Kimura Kaori, Kakimoto Minako, Hiraoka Yumie, Matsukawa Manami, Nagahashi Hiroko, Horiguchi Saki, Toshima Miwa, Tomozawa Chikako, Aitani Miki, Kuwata Takeshi, Yoshida Teruhiko, Hirata Makoto, Tanabe Noriko
Department of Genetic Medicine and Services, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
Department of Genetic Medicine and Services, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-Shi, Chiba, 277-8577, Japan.
Fam Cancer. 2025 Sep 3;24(3):66. doi: 10.1007/s10689-025-00496-2.
This study aimed to develop and validate a Multidimensional Impact of Cancer Risk Assessment questionnaire-Japanese version (MICRA-J) as an assessment of the psychosocial impact of genetic testing. The MICRA was translated into Japanese using standardized translation procedures. The reliability and validity of the MICRA-J were evaluated in individuals who underwent BRCA1/2 testing for hereditary breast and ovarian cancer diagnosis. The 72 respondents included patients with BRCA1/2 pathogenic variants (n = 20), BRCA1/2 negative (n = 35), variants of uncertain significance (VUS, n = 6), participants with cascade testing positive (n = 7), and participants with cascade testing negative (n = 4). Total MICRA-J scores were positively correlated with Hospital Anxiety and Depression Scale (HADS) scores and negatively correlated with the 36-item short-form version 2 acute (SF-36v2 acute) scores (P < 0.05). The MICRA-J showed good internal consistency coefficients (α > 0.70). Furthermore, high test-retest correlations were obtained when the 64 participants responded to the MICRA-J twice within a short period (Pearson's correlation coefficient = 0.85). The MICRA-J Total score was higher in the groups with BRCA1/2 pathogenic variant carriers than in the BRCA1/2 negative group, whereas the HADS and SF36v2 acute did not differ significantly. These results suggest that the reliability and validity of the MICRA-J have been established. The MICRA-J, similar to the MICRA in other languages, is considered a useful tool to specifically measure the psychosocial impact of genetic testing.
本研究旨在开发并验证癌症风险评估多维影响问卷日语版（MICRA-J），以评估基因检测对心理社会的影响。使用标准化翻译程序将MICRA翻译成日语。在接受BRCA1/2检测以诊断遗传性乳腺癌和卵巢癌的个体中评估MICRA-J的信度和效度。72名受访者包括携带BRCA1/2致病变异的患者（n = 20）、BRCA1/2阴性者（n = 35）、意义未明变异（VUS，n = 6）、级联检测阳性的参与者（n = 7）和级联检测阴性的参与者（n = 4）。MICRA-J总分与医院焦虑抑郁量表（HADS）得分呈正相关，与简明健康状况调查简表2急性版（SF-36v2急性）得分呈负相关（P < 0.05）。MICRA-J显示出良好的内部一致性系数（α > 0.70）。此外，当64名参与者在短时间内两次回答MICRA-J时，获得了较高的重测相关性（Pearson相关系数 = 0.85）。携带BRCA1/2致病变异的组中MICRA-J总分高于BRCA1/2阴性组，而HADS和SF36v2急性版得分无显著差异。这些结果表明MICRA-J的信度和效度已经确立。与其他语言版本的MICRA一样，MICRA-J被认为是专门衡量基因检测对心理社会影响的有用工具。
