Sasaki Eiichi, Masago Katsuhiro, Fujita Yasuko
Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan.
Division of Translational Oncoimmunology, Aichi Cancer Center Research Institute, Nagoya, Japan.
Virchows Arch. 2025 Sep 3. doi: 10.1007/s00428-025-04240-0.
Basal cell adenoma (BCA) with S100-positive stroma exhibits tricellular differentiation, consisting of bilayered epithelial cells and S100-positive spindle-shaped stromal cells. While the neoplastic nature of the stromal component has been supported by multiple lines of evidence, its myoepithelial origin, suggested by ultrastructural analysis, has not yet been confirmed by other methodological approaches. This mini-review summarizes the key findings of ultrastructural, immunohistochemical and molecular studies with a particular emphasis on the biological nature of the stromal component. Elucidating the lineage and molecular profile of this unique stroma may contribute to a more refined classification and enhance our understanding of salivary gland tumors.
具有S100阳性基质的基底细胞腺瘤（BCA）表现出三细胞分化，由双层上皮细胞和S100阳性梭形基质细胞组成。虽然基质成分的肿瘤性质已得到多方面证据的支持，但其超微结构分析提示的肌上皮起源尚未得到其他方法学研究的证实。本综述总结了超微结构、免疫组织化学和分子研究的关键发现，特别强调了基质成分的生物学性质。阐明这种独特基质的谱系和分子特征可能有助于更精确的分类，并增进我们对涎腺肿瘤的理解。
