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探索严重急性呼吸综合征冠状病毒2(SARS-CoV-2)在胃肠道中的致癌潜力。

Exploring the oncogenic potential of SARS-CoV-2 in the gastrointestinal tract.

作者信息

Miteva Dimitrina Georgieva, Gulinac Milena, Peruhova Milena, Velikova Tsvetelina

机构信息

Department of Genetics, Faculty of Biology, Sofia University St. Kliment Ohridski, Sofia 1164, Bulgaria.

Medical Faculty, Sofia University St. Kliment Ohridski, Sofia 1407, Bulgaria.

出版信息

World J Gastroenterol. 2025 Aug 21;31(31):105665. doi: 10.3748/wjg.v31.i31.105665.

Abstract

Recent research has increasingly highlighted the potential oncogenic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection within the gastrointestinal tract. Growing evidence suggests that SARS-CoV-2 may contribute to the development of gastrointestinal malignancies through several mechanisms, including sustained chronic inflammation, disruption of normal cellular homeostasis, and potential viral integration into host cells. These pathological processes have the potential to dysregulate critical cellular pathways, thereby promoting cancer development in vulnerable populations. A thorough understanding of how SARS-CoV-2 interacts with the development of gastrointestinal cancer is essential for optimizing patient care and establishing comprehensive, long-term monitoring protocols. This review highlighted the pressing need for ongoing research into the complex relationship between SARS-CoV-2 infection and the risk of gastrointestinal cancer.

摘要

最近的研究越来越多地强调了严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染在胃肠道内的潜在致癌作用。越来越多的证据表明,SARS-CoV-2可能通过多种机制促进胃肠道恶性肿瘤的发展,包括持续的慢性炎症、正常细胞稳态的破坏以及病毒潜在地整合到宿主细胞中。这些病理过程有可能失调关键的细胞途径,从而促进易感人群的癌症发展。全面了解SARS-CoV-2如何与胃肠道癌症的发展相互作用,对于优化患者护理和建立全面的长期监测方案至关重要。本综述强调了对SARS-CoV-2感染与胃肠道癌症风险之间复杂关系进行持续研究的迫切需求。

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