Pravdina N F, Veselovskaia T V, Smirnov V D, Galegov G A
Vopr Med Khim. 1985 Sep-Oct;31(5):123-5.
Deoxyadenylylguanosine (dAdG, 0.2-0.4 mM), affecting the RNA polymerase activity, caused inhibition of transcription of the influenza A virus in presence of precursor AdG by 50-60% and a 80-85% inhibition in absence of the precursor. The inhibitor exhibited its effect independently on the time of addition into an incubation mixture. Addition of 0.5 mM inhibitor into a cultural medium inhibited reproduction of the influenza A virus in a culture of chicken embryonal fibroblasts.
脱氧腺苷鸟苷（dAdG，0.2 - 0.4 mM）影响RNA聚合酶活性，在有前体AdG存在的情况下，可使甲型流感病毒的转录受到50 - 60%的抑制，而在前体不存在时抑制率为80 - 85%。该抑制剂的作用不受添加到孵育混合物中的时间影响。向培养基中添加0.5 mM抑制剂可抑制鸡胚成纤维细胞培养物中甲型流感病毒的繁殖。
