Current status and new horizons in stem cell therapy in cardiovascular regenerative medicine (CaVaReM): an update.

Cardiovascular diseases (CVDs) and, consequently, heart failure are life-threatening diseases, and they should be considered a worldwide health primacy. Conventional medical treatments have been unable to tackle the burden of disease thoroughly, and the limited availability of organ donors continues to pose a significant hurdle. This pressing need has prompted researchers to explore innovative regenerative techniques and expedite their progression into clinical trials, instilling fresh hope in patients who do not respond adequately to traditional therapies. Cardiac regeneration is an extensive approach that strives to repair irreversibly damaged heart tissue through groundbreaking scientific advancements, encompassing stem cells, tissue engineering, and cell-free therapies, collectively known as cardiovascular regenerative medicine (CaVaReM). The primary vision for CaVaReM is to develop regenerative-based therapies that can effectively cure cardiovascular disorders. This innovative field focuses on repairing and restoring damaged heart tissue, improving cardiac function, and ultimately enhancing the quality of life (QOL) in patients suffering from heart diseases. This review categorized cardiac regenerative therapies' present status, future opportunities, and challenges.