Wongpipathpong Wannisa, Hirunpat Pornrujee, Kirdlarp Suppachok, Sungkanuparph Somnuek
Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital Mahidol University Samut Prakan Thailand.
J Gen Fam Med. 2025 Jul 16;26(5):485-489. doi: 10.1002/jgf2.70039. eCollection 2025 Sep.
(GBS) is a rare cause of meningitis in healthy adults. We report the case of a healthy 33-year-old man with acute GBS meningitis who experienced relapsed high-grade fever and increased intracranial pressure following completing intravenous antibiotics. A short course of corticosteroids, along with additional antibiotics, improved the cerebrospinal fluid (CSF) profile, and no further complications occurred after the recurrent episodes. The study highlights the need to consider significant CSF inflammation and potential neurological complications in acute GBS meningitis patients, even in the absence of immunodeficiency or previous surgeries. One of the possible routes of infection in our case was suspected from a history of nasal mucosal damage. The importance of careful monitoring and treatment adjustments should be performed and correlated with clinical signs and symptoms.
吉兰-巴雷综合征(GBS)是健康成年人患脑膜炎的罕见病因。我们报告了一例33岁健康男性患急性GBS脑膜炎的病例,该患者在完成静脉抗生素治疗后出现高热复发和颅内压升高。短期使用皮质类固醇激素并联合额外的抗生素治疗改善了脑脊液(CSF)情况,复发后未出现进一步并发症。该研究强调,即使在没有免疫缺陷或既往手术史的情况下,急性GBS脑膜炎患者也需要考虑显著的脑脊液炎症和潜在的神经系统并发症。我们病例中可能的感染途径之一是根据鼻粘膜损伤史怀疑的。应进行仔细监测和调整治疗,并与临床体征和症状相关联。