Cammermeyer J
Acta Anat (Basel). 1977;99(1):21-35. doi: 10.1159/000144831.
The brains and retinas of laboratory animals fixed by perfusion occasionally contain isolated round fat emboli, which increase in number if the two organs are covered with oil during the autopsy. These emboli, in contrast to emboli induced by intravenous injection of oil, are present in smaller numbers, occur without adjacent aggregation of erythrocytes and do not cause widening of the occluded vascular channel. The fat emboli in the normal brain are attributed to connective tissue fat aggregating on the exposed cerebral surface and flowing through openings cut in the leptomeninges and the vascular walls during removal of the brain. Their formation could not be entirely prevented by covering the brain with running water or by submerging the forepart of the animal's body in water during the autopsy. Nevertheless, such a procedure is recommended to avoid introduction of extraneous fat when in a given experiment the question of fat embolism arises. Fat emboli demonstrable in the flattened retina of the cat and the mulatta monkey are ascribed to aspiration of retrobulbar connective tissue fat; they can be prevented by placing a ligature around the optic nerve prior to removal of the eye.
经灌注固定的实验动物的大脑和视网膜偶尔会含有孤立的圆形脂肪栓子，如果在尸检期间这两个器官被油覆盖，其数量会增加。与静脉注射油诱导的栓子不同，这些栓子数量较少，不会伴有相邻红细胞聚集，也不会导致阻塞血管通道增宽。正常大脑中的脂肪栓子归因于结缔组织脂肪聚集在暴露的脑表面，并在移除大脑过程中通过软脑膜和血管壁上切开的开口流动。在尸检期间，用流水覆盖大脑或让动物身体前部浸入水中并不能完全防止其形成。然而，当在特定实验中出现脂肪栓塞问题时，建议采取这种操作以避免引入外来脂肪。在猫和恒河猴扁平的视网膜中可证实的脂肪栓子归因于球后结缔组织脂肪的吸入；在摘除眼球之前围绕视神经放置结扎线可以预防这些脂肪栓子。
