Miao Gelan, Chen Dexiu, Yang Xuelian, Yang Yulian, Jiang Qidong, Liu Li, Lei Xianying
Department of Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Department of Anesthesiology, The First Affiliated Hospital of Southwest Medical University, Luzhou, China.
Sci Prog. 2025 Jul-Sep;108(3):368504251363429. doi: 10.1177/00368504251363429. Epub 2025 Sep 4.
ObjectiveTo evaluate the diagnostic value of tumor protein translationally-controlled 1 (TPT1) in patients with sepsis and septic shock in the intensive care unit (ICU).MethodsThis single-center, prospectively planned observational study included 53 ICU patients with sepsis (30 with non-shock sepsis, 23 with septic shock) and 20 non-infected ICU controls. Plasma levels of TPT1, procalcitonin (PCT), and C-reactive protein (CRP) were measured on day 1 of ICU admission. Diagnostic performance was assessed using receiver operating characteristic (ROC) analysis.ResultsTPT1 levels were associated with higher SOFA scores and serum creatinine levels ( < 0.01). TPT1 levels were consistently significantly higher in non-shock sepsis and septic shock patients than in non-infected controls ( < 0.001). On day 1, plasma TPT1 levels effectively differentiated non-shock from septic shock ( < 0.01). TPT1 has good diagnostic value for sepsis and septic shock (AUC 0.80 and 0.94, respectively, < 0.0001). TPT1 levels were significantly elevated in both non-shock sepsis and septic shock groups compared to non-infected controls ( < 0.001). TPT1 also showed a positive correlation with SOFA score and serum creatinine ( < 0.01). The area under the ROC curve (AUC) for TPT1 was 0.80 for sepsis and 0.94 for septic shock ( < 0.0001), indicating moderate to high diagnostic accuracy. TPT1 outperformed CRP and PCT in distinguishing septic shock from non-shock sepsis (AUC = 0.71).ConclusionsTPT1 has significant value as a diagnostic marker in sepsis and septic shock, with diagnostic capabilities comparable to procalcitonin and C-reactive protein.
目的
评估肿瘤蛋白翻译调控1（TPT1）在重症监护病房（ICU）脓毒症和脓毒性休克患者中的诊断价值。
方法
这项单中心、前瞻性计划的观察性研究纳入了53例ICU脓毒症患者（30例非休克性脓毒症患者，23例脓毒性休克患者）和20例非感染性ICU对照。在ICU入院第1天测量血浆TPT1、降钙素原（PCT）和C反应蛋白（CRP）水平。使用受试者工作特征（ROC）分析评估诊断性能。
结果
TPT1水平与较高的序贯器官衰竭评估（SOFA）评分和血清肌酐水平相关（<0.01）。非休克性脓毒症和脓毒性休克患者的TPT1水平始终显著高于非感染性对照（<0.001）。在第1天，血浆TPT1水平可有效区分非休克性脓毒症和脓毒性休克（<0.01）。TPT1对脓毒症和脓毒性休克具有良好的诊断价值（AUC分别为0.80和0.94，<0.0001）。与非感染性对照相比，非休克性脓毒症和脓毒性休克组的TPT1水平均显著升高（<0.001）。TPT1还与SOFA评分和血清肌酐呈正相关（<0.01）。TPT1的ROC曲线下面积（AUC）对于脓毒症为0.80，对于脓毒性休克为0.94（<0.0001），表明诊断准确性为中度至高。在区分脓毒性休克与非休克性脓毒症方面，TPT1优于CRP和PCT（AUC = 0.71）。
结论
TPT1作为脓毒症和脓毒性休克的诊断标志物具有重要价值，其诊断能力与降钙素原和C反应蛋白相当。
