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针对皮肤癣菌的卫生措施:对抗真菌耐药性的策略综述

Hygiene Practices Against Dermatophytic Fungi: A Review of Strategies to Combat Antifungal Resistance.

作者信息

Gupta Aditya K, Taylor Daniel, Wang Tong, Cooper Elizabeth A, Saunte Ditte Marie L

机构信息

Division of Dermatology, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A1, Canada.

Mediprobe Research Inc., London, ON N5X 2P1, Canada.

出版信息

Biology (Basel). 2025 Aug 7;14(8):1016. doi: 10.3390/biology14081016.

Abstract

Superficial fungal infections of the feet, such as tinea pedis and onychomycosis, are highly prevalent and frequently recurrent, often due to persistent contamination of footwear, textiles, and foot care instruments. Despite growing concern over antifungal resistance, environmental sources of reinfection remain under-recognized in clinical practice. This review critically examines historical and contemporary methods used to sanitize shoes, socks, podiatric tools, and related materials. Evidence from peer-reviewed studies published between 1938 and 2025 was analyzed across multiple disinfection categories, including chemical agents, thermal methods, laundering, ultraviolet- and ozone-based technologies, antimicrobial textiles, and sterilization protocols. Findings reveal a range of efficacies, limitations, and practical considerations across methods, with steam sterilization emerging as the most reliable for reusable instruments. A multifaceted approach combining pharmacologic treatment with consistent environmental hygiene is essential for breaking reinfection cycles and reducing antifungal resistance. This review highlights the need for clinical education and research into scalable, effective disinfection strategies.

摘要

足部浅表真菌感染,如足癣和甲癣,非常普遍且经常复发,这通常是由于鞋类、纺织品和足部护理工具持续受到污染所致。尽管人们越来越关注抗真菌耐药性,但在临床实践中,再感染的环境来源仍未得到充分认识。本综述批判性地研究了用于清洁鞋子、袜子、足部护理工具及相关材料的历史方法和现代方法。分析了1938年至2025年间发表的同行评审研究中关于多种消毒类别的证据,包括化学试剂、热方法、洗涤、紫外线和臭氧技术、抗菌纺织品以及灭菌方案。研究结果揭示了各种方法的一系列有效性、局限性和实际考量因素,其中蒸汽灭菌对于可重复使用的器械而言是最可靠的方法。将药物治疗与持续的环境卫生相结合的多方面方法对于打破再感染循环和降低抗真菌耐药性至关重要。本综述强调了临床教育以及对可扩展、有效消毒策略进行研究的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e08d/12383997/98c9b9ef8617/biology-14-01016-g001.jpg

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