Radu Cosmin-George, Rădăvoi George Daniel, Aurelian Justin, Achim Ion-Florin, Andras Iulia, Buzoianu Maximilian, Hiriscau Elisabeta Ioana, Crisan Nicolae, Grama Florin, Constantinoiu Silviu, Jinga Viorel
Chirurgia (Bucur). 2025 Aug;120(4):446-458. doi: 10.21614/chirurgia.3156.
Radical cystectomy with ileal conduit urinary diversion (Bricker technique) remains the standard treatment for localized muscle-invasive bladder cancer (MIBC), as well as for high-risk non-muscle-invasive bladder cancer (NMIBC). Amid the transition toward minimally invasive techniques, comparing laparoscopic radical cystectomy (LRC) with robot-assisted radical cystectomy (RARC) becomes essential, particularly regarding perioperative morbidity and postoperative health-related quality of life. However, real-world data from Eastern Europe remain limited. Objective: To compare peri- and postoperative clinical outcomes and quality of life in patients undergoing radical cystectomy with Bricker urinary diversion via laparoscopic versus robotic approach. This is a retrospective, observational study conducted between March 2023 and March 2025 in two academic centers in Cluj-Napoca, Romania. A total of 37 patients diagnosed with MIBC were included and allocated into two groups based on the surgical approach: laparoscopic (n=22) and robotic (n=15). Clinical, biological, and surgical parameters were collected pre- and postoperatively. Quality of life was assessed at 3 months using the EQ-5D-5L and EQ-VAS instruments. Statistical analyses included t-tests, Mann-Whitney U tests, linear regression models, and correlation coefficients, with a significance threshold of p 0.05. The robotic group demonstrated significantly better postoperative renal function (eGFR: 84.2 +- 5.88 vs. 66.55 +- 5.59 ml/min/1.73m²; p=0.041) and a shorter median hospital stay (7 days, IQR 6â?"8 vs. 9 days, IQR 7â?"13; p=0.045), despite a longer operative time (463 +- 25.4 vs. 415 +- 21.52 minutes). Severe postoperative complications were significantly more frequent in the laparoscopic group (54.5% vs. 6.7%; p=0.004). Preexisting urinary tract infections, more common in the LRC group (45.5% vs. 20%), were independently associated with decreased postoperative renal function (ò = -0.39, p=0.005). The mean EQ-VAS score was higher in the robotic group (84.93 +- 2.64 vs. 76.81 +- 4.42; p 0.01), despite a lower EQ-5D-5L utility index (0.52 +- 0.12 vs. 0.72 +- 0.05; p=0.02), indicating an overall favorable health perception despite objectively reduced functional outcomes. Postoperative complications were significantly correlated with decreased EQ-VAS scores (71.39 +- 20.49 vs. 88.37 +- 71.13; p=0.004). In the real-world clinical setting of Eastern Europe, the robotic approach to radical cystectomy with Bricker urinary diversion was associated with better preserved renal function, shorter hospitalization and a lower incidence of severe complications. Preoperative urinary tract infections negatively impacted renal function independently of baseline eGFR. Although RARC patients showed more pronounced functional impairments as measured by EQ-5D-5L, their overall health perception (EQ-VAS) was significantly better, suggesting the influence of technological expectations and postoperative satisfaction. These results support the implementation of robotic surgery in advanced urological centers and highlight the need for prospective, randomized trials with extended follow-up focusing on functional outcomes and quality of life.
根治性膀胱切除术联合回肠导管尿流改道术(Bricker术式)仍然是局限性肌层浸润性膀胱癌(MIBC)以及高危非肌层浸润性膀胱癌(NMIBC)的标准治疗方法。在向微创技术转变的过程中,比较腹腔镜根治性膀胱切除术(LRC)和机器人辅助根治性膀胱切除术(RARC)变得至关重要,尤其是在围手术期发病率和术后健康相关生活质量方面。然而,来自东欧的真实世界数据仍然有限。目的:比较通过腹腔镜与机器人手术方式行Bricker尿流改道的根治性膀胱切除术患者的围手术期和术后临床结局及生活质量。这是一项回顾性观察研究,于2023年3月至2025年3月在罗马尼亚克卢日-纳波卡的两个学术中心进行。共纳入37例诊断为MIBC的患者,并根据手术方式分为两组:腹腔镜组(n = 22)和机器人手术组(n = 15)。术前和术后收集临床、生物学和手术参数。使用EQ-5D-5L和EQ-VAS工具在3个月时评估生活质量。统计分析包括t检验、Mann-Whitney U检验、线性回归模型和相关系数,显著性阈值为p < 0.05。机器人手术组术后肾功能明显更好(估算肾小球滤过率:84.2±5.88 vs. 66.55±5.59 ml/min/1.73m²;p = 0.041),中位住院时间更短(7天,四分位间距IQR 6 - 8 vs. 9天,IQR 7 - 13;p = 0.045),尽管手术时间更长(463±25.4 vs. 415±21.52分钟)。腹腔镜组严重术后并发症明显更常见(54.5% vs. 6.7%;p = 0.004)。术前存在的尿路感染在LRC组更常见(45.5% vs. 20%),与术后肾功能下降独立相关(β = -0.39,p = 0.005)。机器人手术组的平均EQ-VAS评分更高(84.93±2.64 vs. 76.81±4.42;p < 0.01),尽管EQ-5D-5L效用指数较低(0.52±0.12 vs. 0.72±0.05;p = 0.02),这表明尽管客观功能结局有所下降,但总体健康感知良好。术后并发症与EQ-VAS评分降低显著相关(71.39±20.49 vs. 88.37±71.13;p = 0.004)。在东欧的真实世界临床环境中,采用机器人手术方式行Bricker尿流改道的根治性膀胱切除术与更好地保留肾功能、缩短住院时间以及严重并发症发生率较低相关。术前尿路感染独立于基线估算肾小球滤过率对肾功能产生负面影响。尽管通过EQ-5D-5L测量,RARC患者显示出更明显的功能障碍,但他们的总体健康感知(EQ-VAS)明显更好,这表明技术期望和术后满意度的影响。这些结果支持在先进的泌尿外科中心实施机器人手术,并强调需要进行前瞻性、随机试验,并进行长期随访,重点关注功能结局和生活质量。