Carver Annemarie J, Fairbairn Faith M, Taylor Robert J, Boggarapu Shanmukh, Kamau Njenga R, Gajmer Amrita, Stevens Hanna E
Interdisciplinary Graduate Program in Genetics, University of Iowa, IA, USA; Department of Psychiatry, Carver College of Medicine, University of Iowa, IA, USA; Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, IA, USA.
Department of Psychiatry, Carver College of Medicine, University of Iowa, IA, USA; Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, IA, USA.
Exp Neurol. 2025 Sep 2;394:115453. doi: 10.1016/j.expneurol.2025.115453.
Insulin-like growth factor 1 (IGF1) is primarily produced in the placenta and is essential for neurodevelopment. Specifically, how placental IGF1 production persistently influences the brain is unclear, but with rates of complicated pregnancies on the rise, understanding placental contributions to child outcomes is paramount. We hypothesize that placental Igf1 expression alters fetal neurodevelopment relevant to neurodevelopmental disorders. Therefore, this study evaluated the effects of placental Igf1 overexpression on embryonic and postnatal brain development, particularly for striatum, a region highly linked to neurodevelopmental disorders. Placental overexpression altered placenta structure and function distinctly in females and males. Early differences in placental function altered the trajectory of striatal development, as adult females showed persistent changes in striatal cell composition and behavior while males were less affected. Overall, these results demonstrate that placental Igf1 expression alters striatal development and behavior relevant to neurodevelopmental disorders. These findings expand our understanding of placental influence on neurodevelopment and will aid in targeting placental biology in preventive interventions.
胰岛素样生长因子1（IGF1）主要在胎盘中产生，对神经发育至关重要。具体而言，胎盘产生的IGF1如何持续影响大脑尚不清楚，但随着复杂妊娠率的上升，了解胎盘对儿童结局的影响至关重要。我们假设胎盘Igf1表达会改变与神经发育障碍相关的胎儿神经发育。因此，本研究评估了胎盘Igf1过表达对胚胎期和出生后脑发育的影响，特别是对纹状体的影响，纹状体是一个与神经发育障碍高度相关的区域。胎盘过表达在雌性和雄性中对胎盘结构和功能的改变明显不同。胎盘功能的早期差异改变了纹状体发育的轨迹，成年雌性的纹状体细胞组成和行为出现持续变化，而雄性受影响较小。总体而言，这些结果表明胎盘Igf1表达会改变与神经发育障碍相关的纹状体发育和行为。这些发现扩展了我们对胎盘对神经发育影响的理解，并将有助于在预防性干预中针对胎盘生物学进行研究。
