Lang Zhongliang, Yin Guangdi, Zhang Qiusheng, Zhong Xiaohong, Lin Tao, Lv Jing, Wang Qiang, Zhao Liping
Department of Plastic Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, Anhui, P.R. China.
School of Biomedical Engineering, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, Anhui, P.R. China.
Aesthetic Plast Surg. 2025 Sep 4. doi: 10.1007/s00266-025-05219-7.
Hypertrophic scarring is a common pathological condition often associated with significant clinical symptoms. In pediatric patients, it can impair function and is difficult to treat due to the limited availability of effective treatment options.
To investigate the efficacy of pulsed dye and fractional CO laser combined with ultrasound-assisted transdermal drug delivery technology in the treatment of hypertrophic scars in pediatric patients.
A retrospective cohort study and a self-controlled before-and-after method were used. Thirty-six patients with 41 sites of hypertrophic scars who visited our hospital between July 2022 and December 2023 were included, comprising 18 males and 18 females, aged 2-17 years. All patients underwent a combination of pulsed dye and fractional CO laser treatment, followed by the triamcinolone acetonide using ultrasound-assisted transdermal drug delivery technique. A second combined treatment was performed after an interval of 6-8 weeks. Scars were assessed by physicians and parents using the Patient and Observer Scar Assessment Scale (POSAS) before the first treatment, and at 6 and 12 months after the final treatment. Family satisfaction with treatment efficacy was evaluated at both 6 and 12 months post-treatment, and overall satisfaction was documented at each follow-up.
The study revealed a notable decline in the total patient and observer scar scale scores (74.3±4.7 versus 23.6±2.9), with a P-value of less than 0.001 for each specific POSAS score item at the 12 months follow-up period in comparison to the baseline. The overall satisfaction rate was 98%, and no serious adverse reactions were observed during the follow-up period.
Pulsed dye and fractional CO laser combined with ultrasound-assisted transdermal drug delivery technique demonstrates excellent therapeutic efficacy in the treatment of hypertrophic scars in children. The treatment is associated with minimal discomfort, high patient compliance, and no significant adverse reactions.
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肥厚性瘢痕是一种常见的病理状况，常伴有明显的临床症状。在儿科患者中，它会影响功能，且由于有效治疗选择有限而难以治疗。
探讨脉冲染料激光和分数二氧化碳激光联合超声辅助透皮给药技术治疗儿科患者肥厚性瘢痕的疗效。
采用回顾性队列研究和自身前后对照法。纳入2022年7月至2023年12月期间到我院就诊的36例有41处肥厚性瘢痕的患者，其中男性18例，女性18例，年龄2至17岁。所有患者均接受脉冲染料激光和分数二氧化碳激光联合治疗，随后采用超声辅助透皮给药技术给予曲安奈德。间隔6至8周后进行第二次联合治疗。在首次治疗前、最后一次治疗后6个月和12个月，由医生和家长使用患者和观察者瘢痕评估量表（POSAS）对瘢痕进行评估。在治疗后6个月和12个月评估家庭对治疗效果的满意度，并在每次随访时记录总体满意度。
研究显示患者和观察者瘢痕量表总分显著下降（74.3±4.7对23.6±2.9），与基线相比，在12个月随访期的每个特定POSAS评分项目的P值均小于0.001。总体满意率为98%，随访期间未观察到严重不良反应。
脉冲染料激光和分数二氧化碳激光联合超声辅助透皮给药技术在治疗儿童肥厚性瘢痕方面显示出优异的治疗效果。该治疗方法不适反应最小，患者依从性高，且无明显不良反应。
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