Barreto Cruz Yeidaliz, Grado Gordon L
Radiology-Oncology, Universidad Autónoma de Gualajara, Guadalajara, MEX.
Radiation Oncology, Southwest Oncology Centers, Scottsdale, USA.
Cureus. 2025 Aug 4;17(8):e89374. doi: 10.7759/cureus.89374. eCollection 2025 Aug.
Neuroendocrine tumors (NETs) originate from neuroendocrine cells, which receive neural input and play a key role in transmitting signals by secreting bioactive substances such as monoamines (e.g., serotonin), peptides (e.g., somatostatin), and hormones (e.g., insulin) that regulate a wide range of physiological functions. While NETs in the liver are typically metastatic, often originating from other sites in the gastrointestinal (GI) tract, they can, in rare cases, manifest as primary tumors in the liver. These are referred to as primary hepatic neuroendocrine tumors (PHNT). We present the case of a 62-year-old male patient diagnosed with PHNT confirmed through imaging and immunohistochemistry analysis. Given the rarity of this diagnosis, there are no established treatment guidelines for PHNT. In this case, lattice radiotherapy (LRT) via TomoTherapy (TomoTherapy, Inc. in Madison, WI) was selected as the first-line treatment approach for the tumor.
神经内分泌肿瘤（NETs）起源于神经内分泌细胞，这些细胞接收神经输入，并通过分泌生物活性物质（如单胺类物质，如血清素；肽类物质，如生长抑素；以及激素，如胰岛素）来传递信号，从而在调节广泛生理功能方面发挥关键作用。虽然肝脏中的神经内分泌肿瘤通常是转移性的，往往起源于胃肠道（GI）的其他部位，但在极少数情况下，它们可表现为肝脏原发性肿瘤。这些被称为原发性肝神经内分泌肿瘤（PHNT）。我们报告了一例62岁男性患者，经影像学和免疫组化分析确诊为PHNT。鉴于该诊断罕见，目前尚无针对PHNT的既定治疗指南。在此病例中，通过螺旋断层放疗（TomoTherapy，位于威斯康星州麦迪逊市的TomoTherapy公司）进行的格栅放疗（LRT）被选为该肿瘤的一线治疗方法。
