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一例睾丸癌经博来霉素、依托泊苷和顺铂四周期化疗后孤立性骨转移采用立体定向放射治疗实现完全缓解的病例。

A Case of Complete Remission Achieved Through Stereotactic Radiotherapy for Isolated Bone Metastasis Following Four Courses of Bleomycin, Etoposide, and Cisplatin Chemotherapy for Testicular Cancer.

作者信息

Arinami Kentaro, Kawaguchi Gen, Ito Kozue, Takizawa Yurie, Hasegawa Go, Ikeda Yohei, Hara Noboru, Nishiyama Tsutomu

机构信息

Department of Urology Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital Niigata Japan.

Department of Radiation Oncology Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital Niigata Japan.

出版信息

IJU Case Rep. 2025 Aug 13;8(5):508-512. doi: 10.1002/iju5.70080. eCollection 2025 Sep.

Abstract

INTRODUCTION

We report a case of nonseminoma germ cell tumor, in which solitary bone metastasis was detected by magnetic resonance imaging (MRI) after systemic chemotherapy, and resolution was achieved with stereotactic radiotherapy.

CASE PRESENTATION

A 42-year-old man was diagnosed with right-sided testicular cancer, T1N1M0, and right high orchiectomy was performed. Pathology revealed a mixed germ cell tumor. He received four 3-week courses of chemotherapy (BEP). Although computed tomography showed no new metastases, whole-body MRI revealed a solitary bone metastasis to the left sacrum, and stereotactic radiotherapy of 36.8 Gy/8f was administered to the same area. After radiotherapy, the accumulation in that area disappeared on MRI.

CONCLUSION

As evidence accumulates, it is likely that whole-body MRI will become a useful observational method for staging and monitoring patients with germ cell tumors. Stereotactic radiotherapy may be used as consolidation therapy for patients with residual masses after systemic therapy.

摘要

引言

我们报告一例非精原细胞瘤性生殖细胞肿瘤病例,该病例在全身化疗后通过磁共振成像(MRI)检测到孤立性骨转移,并通过立体定向放射治疗实现了肿瘤消退。

病例介绍

一名42岁男性被诊断为右侧睾丸癌,T1N1M0,接受了右侧高位睾丸切除术。病理显示为混合性生殖细胞肿瘤。他接受了四个为期3周的化疗疗程(BEP方案)。尽管计算机断层扫描未显示新的转移灶,但全身MRI显示左侧骶骨有孤立性骨转移,对同一区域进行了36.8 Gy/8次分割的立体定向放射治疗。放疗后,该区域在MRI上的强化消失。

结论

随着证据的积累,全身MRI很可能成为生殖细胞肿瘤患者分期和监测的有用观察方法。立体定向放射治疗可作为全身治疗后有残留肿块患者的巩固治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4822/12408177/6ab1d3aff0ee/IJU5-8-508-g001.jpg

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