Ran Yue, Ma Yuhan, Luo Yuexin, Ruan Yajun
Second Clinical Department, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Physiol. 2025 Aug 20;16:1633468. doi: 10.3389/fphys.2025.1633468. eCollection 2025.
Ferroptosis is a new type of cell death driven by iron-dependent phospholipid peroxidation, which is regulated by a variety of factors including redox homeostasis, iron metabolism, lipid metabolism, cellular metabolism, and mitochondrial function, and plays an important driving role in the development of various tissues and organ damage and diseases. Kidney stones are a common urological disease characterized by high morbidity and high recurrence rate. Currently available preventive or therapeutic treatments for kidney stones are inadequate to cope with the growing clinical demand, suffering from poor efficacy and a higher risk of postoperative complications. Accumulating experimental evidence has established mechanistic links between ferroptosis and nephrolithiasis pathogenesis, highlighting the promising potential of ferroptosis-based therapeutic strategies in kidney stone treatment. This review delves into the latest advances in ferroptosis research associated with kidney stone formation. We review the latest molecular regulatory mechanisms of ferroptosis associated with kidney stone formation from five aspects and elucidate the physiological functions and pathological roles of these pathways. In the conclusion, we critically analyze the therapeutic potential of targeting key molecular mediators within these pathways, providing strategic insights for developing novel therapeutic interventions that may overcome the limitations of conventional approaches in the future.
铁死亡是一种由铁依赖性磷脂过氧化驱动的新型细胞死亡方式，受氧化还原稳态、铁代谢、脂质代谢、细胞代谢和线粒体功能等多种因素调控，在各种组织器官损伤和疾病的发展过程中发挥着重要的驱动作用。肾结石是一种常见的泌尿系统疾病，发病率高且复发率高。目前可用的肾结石预防或治疗方法不足以满足日益增长的临床需求，存在疗效不佳和术后并发症风险较高的问题。越来越多的实验证据证实了铁死亡与肾结石发病机制之间的机制联系，凸显了基于铁死亡的治疗策略在肾结石治疗中的潜在前景。本综述深入探讨了与肾结石形成相关的铁死亡研究的最新进展。我们从五个方面综述了与肾结石形成相关的铁死亡的最新分子调控机制，并阐明了这些途径的生理功能和病理作用。在结论部分，我们批判性地分析了靶向这些途径中关键分子介质的治疗潜力，为开发可能克服未来传统方法局限性的新型治疗干预措施提供了战略见解。
