Nashwan Nancy Yacoub, Mohamed Shah Noraida, Islahudin Farida, Wasfi Iii Sameh Mohammed
Department of Pharmacy, Turkish Palestinian Friendship Hospital, Gaza, Palestine.
Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Patient Prefer Adherence. 2025 Aug 30;19:2663-2671. doi: 10.2147/PPA.S525593. eCollection 2025.
Cancer-related pain is a critical symptom that significantly impacts patients' quality of life. This study aimed to assess adherence and identify factors influencing adherence to opioid analgesics for cancer-related pain among cancer patients at a hospital setting in Gaza, Palestine.
A cross-sectional study was conducted from December 2021 to March 2022, involving cancer patients receiving opioid for cancer-related pain. Participants completed a set of questionnaires on socioeconomic data, pain intensity and interference using the Brief Pain Inventory (BPI), adherence to opioids using the General Medication Adherence Scale (GMAS), and beliefs about pain and opioids using the Pain and Opioid Analgesic Beliefs-Cancer (POASB-CA) scale. Patients' clinical data were collected from the patients' medical records. Simple and multiple linear regression analyses were utilized to elucidate factors associated with adherence towards opioids for cancer-related pain.
A total of 270 patients were recruited. Most patients (88.5%) were at least partially adherent to the opioid analgesic. The average pain intensity score was 5.796 (SD = 1.98), and pain interference scored 7.093 (SD = 3.63). Simple linear regression identified the following parameters to be significantly associated with adherence: education level, presence of comorbidity, average percentage of pain relief experienced over the past 24 hours, negative effect beliefs and pain endurance beliefs. Based on multiple linear regression analysis, education level, percentage of pain relief and presence of side effects were positive predictors of higher adherence score (B=1.082, CI 0.139 to 2.025, p=0.025; B=0.076, CI 0.046 to 0.105, p<0.001 and B=1.578, CI 0.116 to 3.041, p=0.034, respectively).
Adherence to opioids for cancer-related pain was generally good. Influencing factors included education level, average pain relief in the past 24 hours, and opioid side effects. These results highlight the complex nature of adherence in managing cancer pain and suggest areas for targeted interventions.
癌症相关疼痛是一种严重影响患者生活质量的关键症状。本研究旨在评估巴勒斯坦加沙一家医院环境中癌症患者对阿片类镇痛药治疗癌症相关疼痛的依从性，并确定影响依从性的因素。
于2021年12月至2022年3月进行了一项横断面研究，纳入接受阿片类药物治疗癌症相关疼痛的癌症患者。参与者完成了一系列问卷，内容涉及社会经济数据、使用简明疼痛量表（BPI）评估的疼痛强度和干扰、使用一般药物依从性量表（GMAS）评估的阿片类药物依从性，以及使用疼痛和阿片类镇痛药信念-癌症（POASB-CA）量表评估的对疼痛和阿片类药物的信念。患者的临床数据从患者病历中收集。采用简单和多元线性回归分析来阐明与癌症相关疼痛阿片类药物依从性相关的因素。
共招募了270名患者。大多数患者（88.5%）至少部分依从阿片类镇痛药。平均疼痛强度评分为5.796（标准差=1.98），疼痛干扰评分为7.093（标准差=3.63）。简单线性回归确定以下参数与依从性显著相关：教育水平、合并症的存在、过去24小时内经历的平均疼痛缓解百分比、负面效应信念和疼痛耐力信念。基于多元线性回归分析，教育水平、疼痛缓解百分比和副作用的存在是依从性得分较高的正向预测因素（分别为B = 1.082，可信区间0.139至2.025，p = 0.025；B = 0.076，可信区间0.046至0.105，p < 0.001；B = 1.578，可信区间0.116至3.041，p = 0.034）。
癌症相关疼痛患者对阿片类药物的依从性总体良好。影响因素包括教育水平、过去24小时内的平均疼痛缓解情况以及阿片类药物的副作用。这些结果凸显了癌症疼痛管理中依从性的复杂性，并提示了有针对性干预的领域。
