Liu Meihua, Wang Jingyi, Song Zhen, Pei Yong
Research Center of Emotional Diseases, Shenyang Anning Hospital, Shenyang, China.
Second Clinical College, China Medical University, Shenyang, China.
Front Pharmacol. 2025 Aug 20;16:1642248. doi: 10.3389/fphar.2025.1642248. eCollection 2025.
Curcumin, a natural polyphenolic compound derived from , has shown great potential in the prevention and treatment of chronic inflammatory diseases due to its significant antioxidant and anti-inflammatory properties. This article aims to systematically review the anti-inflammatory molecular mechanism, clinical application prospects and challenges of curcumin. By searching the databases of Web of Science, PubMed, Google Scholar and CNKI, and integrating the latest research progress, it was found that curcumin exerted its core anti-inflammatory effects mainly by inhibiting the activation of nuclear factor-κB (NF-κB) signaling pathway, regulating the mitogen-activated protein kinase extracellular signal-regulated kinase (ERK) phosphorylation cascade, and regulating the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. Pharmacological studies have confirmed the therapeutic value of curcumin in a variety of inflammation-related diseases, including neurodegenerative diseases, inflammatory bowel disease, atherosclerosis, diabetes and tumors. Although curcumin has good safety and extensive sources, its inherent low bioavailability severely limits its clinical application. This review points out that combining cutting-edge technologies such as new nano-delivery systems, optimizing the delivery efficiency of curcumin and exploring its anti-inflammatory mechanism in depth are the focus of future research, which is expected to promote it to become a more effective clinical anti-inflammatory drug.
姜黄素是一种从[具体来源未给出]提取的天然多酚化合物，因其具有显著的抗氧化和抗炎特性，在慢性炎症性疾病的预防和治疗中显示出巨大潜力。本文旨在系统综述姜黄素的抗炎分子机制、临床应用前景及挑战。通过检索科学网、PubMed、谷歌学术和中国知网等数据库，并整合最新研究进展，发现姜黄素主要通过抑制核因子-κB（NF-κB）信号通路的激活、调节丝裂原活化蛋白激酶细胞外信号调节激酶（ERK）磷酸化级联反应以及调节Janus激酶/信号转导子和转录激活子（JAK/STAT）途径发挥其核心抗炎作用。药理学研究已证实姜黄素在多种炎症相关疾病中的治疗价值，包括神经退行性疾病、炎症性肠病、动脉粥样硬化、糖尿病和肿瘤。尽管姜黄素具有良好的安全性和广泛的来源，但其固有的低生物利用度严重限制了其临床应用。本综述指出，结合新型纳米递送系统等前沿技术、优化姜黄素的递送效率并深入探索其抗炎机制是未来研究的重点，有望促使其成为一种更有效的临床抗炎药物。
