Aliyari Mahdieh, Ghoflchi Sahar, Hashemy Seyed Isaac, Hashemi Seyedeh Fatemeh, Reihani Amirali, Hosseini Hossein
Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Diabetes Metab Disord. 2025 Jan 17;24(1):52. doi: 10.1007/s40200-025-01563-2. eCollection 2025 Jun.
The purpose of this review study is to investigate the effect of curcumin on the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway in various diseases. Curcumin, the main compound found in turmeric, has attracted a lot of attention for its diverse pharmacological properties. These properties have increased the therapeutic potential of curcumin in chronic diseases such as cardiovascular disease, Type 2 diabetes, obesity, non-alcoholic fatty liver disease, kidney disease, and neurodegenerative diseases. One of the main mechanisms of the effect of curcumin on health is its ability to modulate the PI3K/Akt signaling pathway. This pathway plays an important role in regulating vital cellular processes such as growth, cell survival, metabolism, and apoptosis. Disruption of the PI3K/Akt signaling pathway is associated with the incidence of several diseases.
Electronic databases including PubMed, Google Scholar, and Scopus were searched with the keywords "phosphoinositide 3-kinase" AND "protein kinase B "AND "curcumin" in the title/abstract. Also, following keywords "non-alcoholic fatty liver disease" AND "diabetes" AND "obesity" AND "kidney disease" and "neurodegenerative diseases" was searched in the whole text.
Research indicates that curcumin offers potential benefits for several health conditions. Studies have shown it can help regulate blood sugar, reduce inflammation, and protect the heart, kidneys, and brain.
This protective effect is partially achieved by regulating the PI3K-Akt survival pathway, which helps improve metabolic disorders and oxidative stress. By examining how curcumin affects this vital cell pathway, researchers can discover new treatment strategies for a range of diseases.
本综述研究旨在探讨姜黄素对各种疾病中磷酸肌醇3激酶（PI3K）/蛋白激酶B（Akt）信号通路的影响。姜黄素是姜黄中的主要化合物，因其多样的药理特性而备受关注。这些特性增加了姜黄素在心血管疾病、2型糖尿病、肥胖症、非酒精性脂肪性肝病、肾病和神经退行性疾病等慢性疾病中的治疗潜力。姜黄素对健康产生影响的主要机制之一是其调节PI3K/Akt信号通路的能力。该信号通路在调节生长、细胞存活、代谢和凋亡等重要细胞过程中发挥着重要作用。PI3K/Akt信号通路的破坏与多种疾病的发生有关。
在PubMed、谷歌学术和Scopus等电子数据库中，以标题/摘要中包含关键词“磷酸肌醇3激酶”、“蛋白激酶B”和“姜黄素”进行检索。此外，在全文中检索以下关键词“非酒精性脂肪性肝病”、“糖尿病”、“肥胖症”、“肾病”和“神经退行性疾病”。
研究表明，姜黄素对多种健康状况具有潜在益处。研究表明，它有助于调节血糖、减轻炎症，并保护心脏、肾脏和大脑。
这种保护作用部分是通过调节PI3K - Akt存活信号通路实现的，该通路有助于改善代谢紊乱和氧化应激。通过研究姜黄素如何影响这一重要的细胞信号通路，研究人员可以发现一系列疾病的新治疗策略。
