Ritz E, Mehls O, Krempien B, Gilli G, Udes H, Harendza W
Adv Exp Med Biol. 1977;81:515-31. doi: 10.1007/978-1-4613-4217-5_51.
Stable long-term chronic renal failure in the growing Sprague Dawley rat causes marked bone disease with impaired mineralization (i.e. rickets) and evidence of increased parathyroid hormone activity. Although significant bone disease is present, the rate of longitudinal growth is not diminished in preterminal renal failure. However, it is significantly diminished in terminal renal failure, when uremic rats are compared with sham-operated control rats at identical levels of food intake. At identical levels of food intake, weight gain is also diminished in rats with terminal uremia as compared with sham-operated control rats, suggesting increased calorie cost for growth.
生长中的斯普拉格-道利大鼠出现稳定的长期慢性肾衰竭会导致明显的骨病，伴有矿化受损（即佝偻病）以及甲状旁腺激素活性增加的迹象。尽管存在明显的骨病，但在终末期肾衰竭前纵向生长速率并未降低。然而，在终末期肾衰竭时，当将尿毒症大鼠与假手术对照大鼠在相同食物摄入量水平下进行比较时，纵向生长速率会显著降低。在相同食物摄入量水平下，与假手术对照大鼠相比，终末期尿毒症大鼠的体重增加也减少，这表明生长的热量消耗增加。
