Takatsu Yasuo, Nakamura Masafumi, Tateyama Tomoko, Miyati Tosiaki, Kobayashi Satoshi
Department of Molecular Imaging, Clinical Collaboration Unit, School of Medical Sciences, Fujita Health University, 1-98, Dengakugakubo, Kutsukake-Cho, Toyoake, Aichi, 470-1192, Japan.
Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa, 920-0942, Japan.
Radiol Phys Technol. 2025 Sep 5. doi: 10.1007/s12194-025-00933-y.
This study evaluated whether temporal changes from the dynamic late phase to the hepatobiliary phase using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid supported liver tumor classification. A total of 147 patients with 165 lesions (hepatocellular carcinoma [HCC], metastases, and hemangiomas) underwent 3.0 T MRI. Quantitative liver lesion contrast (Q-LLC) and its rate of change (%) at 3, 10, and 15 min postcontrast were analyzed. Tumors were stratified according to albumin-bilirubin (ALBI) grade. For ALBI grade 1, the Q-LLC significantly differed at 3 min and 10 min (P < 0.05). Q-LLC increased over time, and the rate of change was the lowest in HCC, followed by metastases, and was the highest in hemangiomas. Significant differences in the rate of change were observed among tumor types for ALBI grade 1 (P < 0.01). These findings suggest that the Q-LLC rate of change may aid in liver tumor classification, particularly in patients with preserved liver function.
本研究评估了使用钆乙氧基苄基二乙三胺五乙酸从动态晚期到肝胆期的时间变化是否有助于肝脏肿瘤的分类。共有147例患者的165个病灶（肝细胞癌[HCC]、转移瘤和血管瘤）接受了3.0 T磁共振成像（MRI）检查。分析了造影剂注射后3、10和15分钟时的定量肝脏病灶对比（Q-LLC）及其变化率（%）。根据白蛋白-胆红素（ALBI）分级对肿瘤进行分层。对于ALBI 1级，Q-LLC在3分钟和10分钟时存在显著差异（P<0.05）。Q-LLC随时间增加，变化率在HCC中最低，其次是转移瘤，在血管瘤中最高。对于ALBI 1级，不同肿瘤类型的变化率存在显著差异（P<0.01）。这些发现表明，Q-LLC变化率可能有助于肝脏肿瘤的分类，尤其是在肝功能保留的患者中。
