Li Chang-Ping, Wang Ying-Ying, Zhou Ching-Wei, Ding Chen-Yun, Teng Peng, Nie Rui, Yang Shu-Guang
Center for Translational Neural Regeneration Research, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, China.
Cell Regen. 2025 Sep 5;14(1):38. doi: 10.1186/s13619-025-00260-y.
Neural regeneration stands at the forefront of neuroscience, aiming to repair and restore function to damaged neural tissues, particularly within the central nervous system (CNS), where regenerative capacity is inherently limited. However, recent breakthroughs in biotechnology, especially the revolutions in genetic engineering, materials science, multi-omics, and imaging, have promoted the development of neural regeneration. This review highlights the latest cutting-edge technologies driving progress in the field, including optogenetics, chemogenetics, three-dimensional (3D) culture models, gene editing, single-cell sequencing, and 3D imaging. Prospectively, the advancements in artificial intelligence (AI), high-throughput in vivo screening, and brain-computer interface (BCI) technologies promise to accelerate discoveries in neural regeneration further, paving the way for more precise, efficient, and personalized therapeutic strategies. The convergence of these multidisciplinary approaches holds immense potential for developing transformative treatments for neural injuries and neurological disorders, ultimately improving functional recovery.
神经再生处于神经科学的前沿，旨在修复受损神经组织并恢复其功能，特别是在中枢神经系统（CNS）中，其再生能力本身就有限。然而，生物技术的最新突破，尤其是基因工程、材料科学、多组学和成像技术的革命，推动了神经再生的发展。本综述重点介绍了推动该领域进展的最新前沿技术，包括光遗传学、化学遗传学、三维（3D）培养模型、基因编辑、单细胞测序和3D成像。前瞻性地看，人工智能（AI）、高通量体内筛选和脑机接口（BCI）技术的进步有望进一步加速神经再生领域的发现，为更精确、高效和个性化的治疗策略铺平道路。这些多学科方法的融合对于开发针对神经损伤和神经系统疾病的变革性治疗方法具有巨大潜力，最终改善功能恢复。
