Pulitzer D R, Reed R J
Am J Dermatopathol. 1985 Oct;7(5):409-21. doi: 10.1097/00000372-198510000-00003.
Seventy cases of nerve-sheath myxoma, an uncommon cutaneous neoplasm, are reported. Lesions developed most frequently on the face and upper extremities, and affected women about twice as often as men. Their average size was one centimeter. Histologically, the lesions involved the reticular dermis; many extended into the superficial portions of the subcutis. They were composed of fascicles of cells with interconnected cytoplasmic processes. The neoplastic cells were associated with variable amounts of a matrix that was rich in acid mucopolysaccharides. Mitoses were common, but evidently had no prognostic significance. Only one of 70 lesions was recurrent and no metastases are known to have occurred from any. For eight cases, immunoperoxidase staining for S-100 protein was done and all were positive. One lesion showed ultrastructural features of nerve-sheath cells, specifically perineurial cells.
报告了70例神经鞘黏液瘤，这是一种罕见的皮肤肿瘤。病变最常发生于面部和上肢，女性受累的频率约为男性的两倍。它们的平均大小为1厘米。组织学上，病变累及网状真皮；许多病变延伸至皮下组织的浅层。它们由具有相互连接的细胞质突起的细胞束组成。肿瘤细胞与富含酸性黏多糖的不同量基质相关。有丝分裂常见，但显然无预后意义。70个病变中只有1个复发，且已知无一发生转移。对8例进行了S-100蛋白免疫过氧化物酶染色，全部呈阳性。1个病变显示出神经鞘细胞，特别是神经束膜细胞的超微结构特征。
