Rooney Tess A, Knych Heather, Peters Mattison, Gjeltema Jenessa, Field Cara
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA.
San Diego Zoo Wildlife Alliance, San Diego, CA.
Am J Vet Res. 2025 Sep 5;86(12). doi: 10.2460/ajvr.25.05.0178. Print 2025 Dec 1.
Determine the pharmacokinetic parameters of a single dose of gabapentin administered orally in healthy weaned Pacific harbor seal (HS) pups (Phoca vitulina richardii).
In the spring of 2023, rehabilitated HS pups were enrolled in this pharmacokinetic study. Seals were administered 10 mg/kg of gabapentin orally in a fish. A sparse sampling model was employed to collect blood samples from 0.25 to 48 hours after drug administration. Plasma drug concentrations were determined using liquid chromatography-tandem mass spectrometry. Pharmacokinetic parameters were determined using noncompartmental analysis for sparse data.
15 HSs were included in this study. The mean peak plasma concentration was 7,669.4 ng/mL, the mean time to peak plasma concentration was 1 hour, the mean area under the concentration-versus-time curve from time 0 to infinity was 23,811.8 h·ng/mL, and the mean terminal half-life was 1.9 hours. No adverse effects were observed in any HSs.
The plasma concentration of gabapentin that confers analgesia is not known in veterinary species. During this study, mean gabapentin concentrations exceeded the concentration estimated to treat neuropathic pain in humans only at 1 hour.
Gabapentin was rapidly absorbed and eliminated in HSs, indicating that higher dosages and/or frequent dosing of gabapentin may be needed to maintain targeted plasma concentrations in young HSs. Additional studies to investigate the clinical efficacy of gabapentin in veterinary species are warranted, and clinical discretion should be used when applying these results to patients outside of the specific demographic group studied here.
确定单剂量口服加巴喷丁在健康断奶的太平洋斑海豹（HS）幼崽（Phoca vitulina richardii）体内的药代动力学参数。
2023年春季，康复的HS幼崽被纳入该药代动力学研究。海豹经口在鱼中给予10mg/kg的加巴喷丁。采用稀疏采样模型在给药后0.25至48小时采集血样。使用液相色谱-串联质谱法测定血浆药物浓度。使用非房室分析稀疏数据来确定药代动力学参数。
本研究纳入了15只HS。平均血浆峰浓度为7669.4ng/mL，平均达峰时间为1小时，从0至无穷大的浓度-时间曲线下面积平均值为23811.8h·ng/mL，平均末端半衰期为1.9小时。未在任何HS中观察到不良反应。
在兽医物种中，产生镇痛作用的加巴喷丁血浆浓度尚不清楚。在本研究期间，加巴喷丁平均浓度仅在1小时时超过估计用于治疗人类神经性疼痛的浓度。
加巴喷丁在HS中吸收和消除迅速，表明可能需要更高剂量和/或更频繁给药加巴喷丁以维持幼龄HS的目标血浆浓度。有必要进行更多研究以调查加巴喷丁在兽医物种中的临床疗效，并且在将这些结果应用于本研究特定人群之外的患者时应谨慎使用临床判断。
