Mayer N, Zimpfer M
Anaesthesist. 1985 Nov;34(11):556-62.
The effects of enflurane on the function of the chronically ischemic myocardium were studied in nine dogs, 2-8 weeks after implantation of Doppler-ultrasound flow transducers around the circumflex branch of the left coronary artery, of pairs of ultrasonic crystals in normal and ischemic regions of the left ventricle, aortic catheters, and of solid-state left ventricular pressure gauges. Enflurane (2% and 4% inspired) caused an increase in heart rate and dose-dependent decreases in left ventricular pressure, dP/dt, mean arterial pressure and mean circumflex coronary resistance. However, in comparison to the normal myocardium neither exaggerated nor permanent dysfunction of the chronically ischemic but still contracting myocardium was noted. Thus, reduction of coronary perfusion pressure and coronary vasodilatation does not seem to be of major functional significance in determining ischemic left ventricular performance during anesthesia with enflurane.
在九条犬身上研究了安氟醚对慢性缺血心肌功能的影响。这些犬在左冠状动脉回旋支周围植入多普勒超声血流换能器、左心室正常及缺血区域的成对超声晶体、主动脉导管和固态左心室压力计2至8周后进行实验。吸入2%和4%的安氟醚会导致心率增加，左心室压力、dp/dt、平均动脉压和平均回旋冠状动脉阻力呈剂量依赖性降低。然而，与正常心肌相比，未发现慢性缺血但仍在收缩的心肌有过度或永久性功能障碍。因此，在安氟醚麻醉期间，冠状动脉灌注压降低和冠状动脉血管扩张在决定缺血性左心室功能方面似乎没有主要的功能意义。
