Stanescu V, Stanescu R, Maroteaux P
Ann Biol Clin (Paris). 1985;43(5):786-90.
Studies of growing cartilage in cases of chondrodysplasia have demonstrated chondrocytic abnormalities, in particular the presence of abnormal inclusions. The histochemical and microchemical analysis of these inclusions provide valuable information concerning the pathophysiology of these diseases, which involves a variety of mechanisms: disorders of the metabolism of proteoglycans and glycosaminoglycans, collagen, lipids, glycoproteins, disorders of cell division.
对软骨发育异常病例中生长软骨的研究已证实存在软骨细胞异常，尤其是存在异常包涵体。对这些包涵体进行组织化学和微量化学分析可提供有关这些疾病病理生理学的有价值信息，这些疾病涉及多种机制：蛋白聚糖和糖胺聚糖、胶原蛋白、脂质、糖蛋白代谢紊乱，以及细胞分裂紊乱。
