Martin C, Ruperti A, Saux P, Brioche M I, Gouin F
Ann Fr Anesth Reanim. 1985;4(6):521-3. doi: 10.1016/s0750-7658(85)80252-5.
A case of severe agranulocytosis is reported in a 43 year old white male with Guillain-Barré syndrome. This patient was treated for an acute aspiration pneumonia and received several antibiotic regimens. An acute agranulocytosis occurred during the stay in the intensive care unit and was followed by a severe septic shock. Bone marrow aplasia was confirmed by needle aspiration. Metronidazole was withdrawn and agranulocytosis improved within three days. None of the other drugs given to the patient were withdrawn. Another bone marrow examination performed several days later revealed a markedly improved granulopoiesis. The patient died with multiple organ failure. The role of metronidazole is discussed in this case as this drug seemed highly responsible for the observed agranulocytosis.
报告了一例患有格林-巴利综合征的43岁白人男性严重粒细胞缺乏症病例。该患者因急性吸入性肺炎接受治疗，并接受了多种抗生素治疗方案。在重症监护病房住院期间发生了急性粒细胞缺乏症，随后出现严重的感染性休克。经针吸证实为骨髓再生障碍。停用甲硝唑后，粒细胞缺乏症在三天内得到改善。未停用给予该患者的其他药物。几天后进行的另一次骨髓检查显示粒细胞生成明显改善。患者死于多器官功能衰竭。本病例讨论了甲硝唑的作用，因为该药物似乎是观察到的粒细胞缺乏症的高度原因。
