降钙素治疗伴有高磷酸酶血症的遗传性骨发育异常：一项关于骨的影像学和组织学研究

Calcitonin treatment in hereditary bone dysplasia with hyperphosphatasemia: a radiographic and histologic study of bone.

作者信息

Whalen J P, Horwith M, Krook L, MacIntyre I, Mena E, Viteri F, Torun B, Nunez E A

出版信息

AJR Am J Roentgenol. 1977 Jul;129(1):29-35. doi: 10.2214/ajr.129.1.29.

DOI:10.2214/ajr.129.1.29

Abstract

Two children with bone dysplasia with hyperphosphatasemia (juvenile Paget's disease) were treated with synthetic human calcitonin. The progress of bone disease was monitored radiographically and histologically. Pretreatment radiographs showed markedly abnormal bone, characterized by lack of discrete cortex and absence of normal modeling. During treatment a discrete cortex was formed composed of compact bone, and more normal modeling occurred. This coincided with a histologic change from woven bone before treatment to a more lamellar type during treatment.

摘要

两名患有骨发育异常伴高磷酸酶血症（青少年佩吉特病）的儿童接受了合成人降钙素治疗。通过影像学和组织学监测骨病进展。治疗前的X线片显示骨明显异常，表现为皮质不连续和缺乏正常的塑形。治疗期间形成了由密质骨组成的连续皮质，且出现了更正常的塑形。这与组织学变化相吻合，即治疗前为编织骨，治疗期间转变为更具板层状的类型。