Lung Thomas, Hayes Alison, Wen Li Ming, Xu Huilan, Brown Vicki, Baur Louise A, Phongsavan Philayrath, Killedar Anagha
Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia.
Int J Obes (Lond). 2025 Sep 6. doi: 10.1038/s41366-025-01904-4.
This study investigated the cost-effectiveness of an early childhood obesity prevention intervention providing telephone and short message service (SMS) support to mothers of children aged 2-4 years by socioeconomic position (SEP).
A model-based SEP-specific economic evaluation of the intervention was conducted. SEP-specific intervention costs and effects at age 5 years were derived from the trial data and applied to a cohort of 4- to 5-year-old Australian children. We used the validated EQ-EPOCH microsimulation model to predict SEP-specific body mass index (BMI) trajectories, quality-adjusted life years (QALYs) and health care costs until 17 years of age. Incremental cost-effectiveness ratios (ICERs) and acceptability curves were derived for each SEP group, using 2023 Australian dollars (AUD).
From an Australian health payer perspective, the ICERs for the low-SEP group were $131 per BMI unit avoided and $6549 per QALY gained, compared to the high-SEP group at $1161 per BMI unit avoided and $41,462 per QALY gained. Results were robust to sensitivity analyses varying the intervention effect size, intervention costs, healthcare costs, discount rate and disutility from overweight. The probability that the intervention was cost-effective at a willingness-to-pay threshold of $50,000 per QALY gained was extremely high in the low-SEP group (99.7%) and marginally cost-effective in the high-SEP group (49.6%).
A telephone and SMS intervention was more cost-effective in low-SEP groups compared with high-SEP groups. Prioritizing families from socioeconomically disadvantaged backgrounds for this intervention will reduce healthy weight inequalities in childhood.
本研究调查了一项针对2至4岁儿童母亲的幼儿肥胖预防干预措施的成本效益,该干预措施按社会经济地位(SEP)提供电话和短信服务支持。
对该干预措施进行了基于模型的特定SEP经济评估。特定SEP的干预成本和5岁时的效果来自试验数据,并应用于一组4至5岁的澳大利亚儿童。我们使用经过验证的EQ-EPOCH微观模拟模型来预测特定SEP的体重指数(BMI)轨迹、质量调整生命年(QALY)和直至17岁的医疗保健成本。使用2023澳元(AUD)得出每个SEP组的增量成本效益比(ICER)和可接受性曲线。
从澳大利亚医疗支付者的角度来看,低SEP组避免每单位BMI的ICER为131澳元,每获得一个QALY的ICER为6549澳元,而高SEP组避免每单位BMI的ICER为1161澳元,每获得一个QALY的ICER为41462澳元。结果对敏感性分析具有稳健性,敏感性分析改变了干预效果大小、干预成本、医疗保健成本、贴现率和超重带来的负效用。在每获得一个QALY支付意愿阈值为50000澳元的情况下,该干预措施具有成本效益的概率在低SEP组极高(99.7%),在高SEP组略具成本效益(49.6%)。
与高SEP组相比,电话和短信干预在低SEP组中更具成本效益。将社会经济背景不利的家庭作为该干预措施的优先对象将减少儿童期健康体重方面的不平等。