中国油性头皮年轻女性脱发的多维研究
Multidimensional Research on Hair Loss in Young Chinese Females With Oily Scalps.
作者信息
Shao Siqi, Li Benyue, Yang Jie, Qi Fengwei, Liu Qi, Zhao Fengnian
机构信息
School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, People's Republic of China.
Shandong Huawutang Biotechnology Co., Ltd, Jinan, People's Republic of China.
出版信息
J Cosmet Dermatol. 2025 Sep;24(9):e70426. doi: 10.1111/jocd.70426.
BACKGROUND
In recent years, the problem of female alopecia has been increasing and has shown a trend toward youthfulness. However, there are fewer studies on young female alopecia in the existing literature.
AIM
We aimed to study the possible causes of hair loss in young Chinese females aged 18-35 with oily scalps.
METHOD
Scalp physiological parameters were measured by non-invasive measurement techniques, scalp lipids were measured by UPLC-MS/MS, scalp microbiota were measured by macro-genome sequencing, and the results were analyzed in a multidimensional combined analysis.
RESULT
The problematic population showed significant differences in several scalp physiological indices, lipid composition, and microbial community structure compared with the normal population, and eight closely related differential lipids, as well as microorganisms with high relative abundance at the phylum and genus levels, were screened.
CONCLUSION
Abnormalities in specific lipids and metabolic pathways, as well as microbiological changes, are associated with hair loss and oily scalp problems.
背景
近年来，女性脱发问题日益增多，且呈年轻化趋势。然而，现有文献中关于年轻女性脱发的研究较少。
目的
我们旨在研究18 - 35岁油性头皮的中国年轻女性脱发的可能原因。
方法
采用非侵入性测量技术测量头皮生理参数，用超高效液相色谱 - 串联质谱法测量头皮脂质，用宏基因组测序法测量头皮微生物群，并对结果进行多维联合分析。
结果
与正常人群相比，问题人群在几个头皮生理指标、脂质组成和微生物群落结构方面存在显著差异，筛选出了8种密切相关的差异脂质以及在门和属水平上相对丰度较高的微生物。
结论
特定脂质和代谢途径的异常以及微生物学变化与脱发和油性头皮问题有关。
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