Vetterlein F, Schmidt G
Basic Res Cardiol. 1985 Nov-Dec;80(6):661-9. doi: 10.1007/BF01907865.
The minimal coronary vascular resistance was measured in anesthetized rats. For determination of coronary flow a tube system was inserted which directed the blood from the left carotid artery via the right carotid artery into the ostium of the left or the right coronary artery. A drop chamber in the shunt system enabled flow measurement. Maximal vasodilatation was induced by intra-arterial infusion of adenosine. In non-thoracotomized rats vascular resistance decreased to 20.6% and 20.3% of control values in the left and right coronary artery, respectively (23.8 to 4.9 18.2 to 3.7 mmHg X ml-1 X min X g). Thoracotomy led to increased control values (29.3 mmHg X ml-1 X min X g, right coronary artery). Minimal resistance in this latter group was nearly as low as in the closed-chest rats (4.8 mmHg X ml-1 X min X g). It can be assumed that the coronary dilator reserve in the rat lies within the same range as that of larger species e.g. dogs.
在麻醉大鼠中测量最小冠状动脉阻力。为了测定冠状动脉血流量，插入了一个管道系统，该系统将血液从左颈动脉经右颈动脉导入左冠状动脉或右冠状动脉口。分流系统中的滴液室可进行流量测量。通过动脉内输注腺苷诱导最大血管舒张。在未开胸的大鼠中，左、右冠状动脉的血管阻力分别降至对照值的20.6%和20.3%（23.8至4.9、18.2至3.7 mmHg×ml⁻¹×min×g）。开胸导致对照值升高（右冠状动脉为29.3 mmHg×ml⁻¹×min×g）。后一组的最小阻力几乎与闭胸大鼠相同（4.8 mmHg×ml⁻¹×min×g）。可以假定大鼠的冠状动脉扩张储备与较大物种（如狗）处于相同范围内。
