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黑树莓提取物对β-淀粉样蛋白诱导的HT-22细胞毒性的神经保护作用

Neuroprotective Effects of Black Raspberry Extract Against β-Amyloid-Induced Cytotoxicity in HT-22 Cells.

作者信息

Tandoro Yohanes, Chiu Hui-Fang, Shen You-Cheng, Tsou Sing-Hua, Lin Chih-Li, Wang Chin-Kun

机构信息

Department of Nutrition Chung Shan Medical University Taichung Taiwan.

Faculty of Agricultural Technology Widya Mandala Catholic University Surabaya Surabaya Indonesia.

出版信息

Food Sci Nutr. 2025 Sep 4;13(9):e70840. doi: 10.1002/fsn3.70840. eCollection 2025 Sep.

DOI:10.1002/fsn3.70840
PMID:40918171
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12411246/
Abstract

Black raspberry is known to contain a diverse number of phytochemicals, especially polyphenols which have shown health benefits. These compounds might play a role in alleviating β-amyloid (Aβ)-induced neurotoxicity. In this study, we investigated the effect of black raspberry in reducing Aβ toxicity and improving mitochondrial function in the HT-22 cell model. HT-22 cells were co-cultured together with black raspberry extract (BRE) and Aβ and various markers for apoptosis and mitochondrial function were assessed. BRE treatment significantly improved cell viability, reduced reactive oxygen species (ROS) generation, and enhanced mitochondrial biogenesis via upregulation of PGC-1α and Sirt1 expression. Among the isolated fractions, the ethanol fraction (Et-F1) demonstrated the most potent neuroprotective effect. High-performance liquid chromatography identified rutin as a major compound in Et-F1, though it did not account for the full protective effect. In conclusion, our results suggest that BRE might be used as a natural supplementation for combatting Aβ-associated dementia.

摘要

已知黑树莓含有多种植物化学物质，尤其是已显示出对健康有益的多酚类物质。这些化合物可能在减轻β-淀粉样蛋白（Aβ）诱导的神经毒性方面发挥作用。在本研究中，我们在HT-22细胞模型中研究了黑树莓在降低Aβ毒性和改善线粒体功能方面的作用。将HT-22细胞与黑树莓提取物（BRE）和Aβ共同培养，并评估各种凋亡和线粒体功能标志物。BRE处理显著提高了细胞活力，减少了活性氧（ROS）的产生，并通过上调PGC-1α和Sirt1的表达增强了线粒体生物合成。在分离的组分中，乙醇组分（Et-F1）表现出最有效的神经保护作用。高效液相色谱法鉴定芦丁为Et-F1中的主要化合物，但其并未完全解释其保护作用。总之，我们的结果表明，BRE可能用作对抗Aβ相关痴呆的天然补充剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8be/12411246/2b4cd2ba20f4/FSN3-13-e70840-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8be/12411246/efb8d0facd3f/FSN3-13-e70840-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8be/12411246/fce50b13b74d/FSN3-13-e70840-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8be/12411246/8bfd1d5c74e2/FSN3-13-e70840-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8be/12411246/d4a9043ce204/FSN3-13-e70840-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8be/12411246/badfd2876f32/FSN3-13-e70840-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8be/12411246/2b4cd2ba20f4/FSN3-13-e70840-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8be/12411246/efb8d0facd3f/FSN3-13-e70840-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8be/12411246/fce50b13b74d/FSN3-13-e70840-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8be/12411246/8bfd1d5c74e2/FSN3-13-e70840-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8be/12411246/d4a9043ce204/FSN3-13-e70840-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8be/12411246/badfd2876f32/FSN3-13-e70840-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8be/12411246/2b4cd2ba20f4/FSN3-13-e70840-g002.jpg

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Successes and failures: the latest advances in the clinical development of amyloid-β-targeting monoclonal antibodies for treating Alzheimer's disease.成功与失败：用于治疗阿尔茨海默病的靶向淀粉样β蛋白单克隆抗体临床开发的最新进展
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The Role of Microglia with Mitochondrial Dysfunction and Its Therapeutic Prospects in Alzheimer's Disease.
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and Insights into a Broccoli Byproduct as a Healthy Ingredient for the Management of Alzheimer's Disease and Aging through Redox Biology.并深入探讨西兰花副产物作为通过氧化还原生物学来管理阿尔茨海默病和衰老的健康成分。
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