• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

绿茶中的表没食子儿茶素-3-没食子酸酯通过Sirtuin 1信号通路调节自噬和铁死亡，减轻血管衰老和内皮细胞衰老。

Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway.

作者信息

Zhang Yingjie, Wang Tianhu, Wang Linghuan, Fang Zhiyi, Lu Tingting, Chen Sijia, Yan Jin, Qin Cheng, Shen Xiaoying, Kang Na, Tian Lei, Cao Feng

机构信息

Medical School of Chinese PLA, The Second Medical Center, Chinese PLA General Hospital, Beijing 100853, China.

Medicine School of Nankai University, Tianjin 300071, China.

出版信息

ACS Omega. 2025 Aug 19;10(34):38740-38752. doi: 10.1021/acsomega.5c03880. eCollection 2025 Sep 2.

DOI:10.1021/acsomega.5c03880
PMID:40918353
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12409518/
Abstract

Vascular aging is a major risk factor for cardiovascular diseases (CVDs) in the older individuals. Epigallocatechin-3-gallate (EGCG), the primary active compound in green tea, exhibits cardiovascular protective effects. However, its effect and the underlying mechanism of the same on vascular aging remain unclear. Herein, doxorubicin (DOX) was employed to develop an endothelial cell senescence model. results indicated that EGCG alleviates endothelial cell senescence by promoting autophagy and inhibiting ferroptosis, supported by Western blot analysis. animal studies revealed a significant decrease in aortic senescence-associated β-galactosidase (SA-β-gal) positive staining and pulse wave velocity (PWV) in the EGCG group compared with that in the control group ( < 0.001), indicating that EGCG can significantly attenuate vascular aging in mice. Multiple lines of evidence suggest that EGCG alleviates vascular aging by activating sirtuin 1 (SIRT1), which promotes autophagy and inhibits ferroptosis.

摘要

血管老化是老年人患心血管疾病（CVDs）的主要危险因素。表没食子儿茶素-3-没食子酸酯（EGCG）是绿茶中的主要活性成分，具有心血管保护作用。然而，其对血管老化的作用及其潜在机制仍不清楚。在此，使用阿霉素（DOX）建立内皮细胞衰老模型。结果表明，蛋白质免疫印迹分析显示，EGCG通过促进自噬和抑制铁死亡来减轻内皮细胞衰老。动物研究显示，与对照组相比，EGCG组主动脉衰老相关β-半乳糖苷酶（SA-β-gal）阳性染色和脉搏波速度（PWV）显著降低（P<0.001），表明EGCG可显著减轻小鼠血管老化。多项证据表明，EGCG通过激活沉默调节蛋白1（SIRT1）来减轻血管老化，SIRT1可促进自噬并抑制铁死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60bc/12409518/1320584548ea/ao5c03880_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60bc/12409518/f8cccd2c4ab4/ao5c03880_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60bc/12409518/d4ebfec6de3f/ao5c03880_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60bc/12409518/bfec826639e0/ao5c03880_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60bc/12409518/9565c9f7594e/ao5c03880_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60bc/12409518/a011e512cd84/ao5c03880_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60bc/12409518/41a1970bf12f/ao5c03880_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60bc/12409518/1320584548ea/ao5c03880_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60bc/12409518/f8cccd2c4ab4/ao5c03880_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60bc/12409518/d4ebfec6de3f/ao5c03880_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60bc/12409518/bfec826639e0/ao5c03880_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60bc/12409518/9565c9f7594e/ao5c03880_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60bc/12409518/a011e512cd84/ao5c03880_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60bc/12409518/41a1970bf12f/ao5c03880_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60bc/12409518/1320584548ea/ao5c03880_0007.jpg

相似文献

1
Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway.绿茶中的表没食子儿茶素-3-没食子酸酯通过Sirtuin 1信号通路调节自噬和铁死亡，减轻血管衰老和内皮细胞衰老。
ACS Omega. 2025 Aug 19;10(34):38740-38752. doi: 10.1021/acsomega.5c03880. eCollection 2025 Sep 2.
2
Huotan Jiedu Tongluo Decoction targets Nrf2-mediated macrophage autophagy to inhibit ferroptosis and reduce atherosclerotic lesions.化痰解毒通络方通过靶向Nrf2介导的巨噬细胞自噬抑制铁死亡并减少动脉粥样硬化病变。
Phytomedicine. 2025 Jun 23;145:157012. doi: 10.1016/j.phymed.2025.157012.
3
Methylglyoxal-induced glycation stress promotes aortic stiffening: Putative mechanistic roles of oxidative stress and cellular senescence.甲基乙二醛诱导的糖基化应激促进主动脉硬化：氧化应激和细胞衰老的假定机制作用
bioRxiv. 2025 Jan 6:2025.01.06.631561. doi: 10.1101/2025.01.06.631561.
4
Epigallocatechin-3-gallate mitigates postovulatory oocyte aging by reducing oxidative stress and promoting embryonic development.表没食子儿茶素-3-没食子酸酯通过降低氧化应激和促进胚胎发育来减轻排卵后卵母细胞衰老。
Reproduction. 2025 Jun 25;170(1). doi: 10.1530/REP-25-0125. Print 2025 Jul 1.
5
Paclitaxel Attenuates Atherosclerosis by Suppressing Macrophage Ferroptosis and Improving Lipid Metabolism via the Sirt1/Nrf2/GPX4 Pathway.紫杉醇通过Sirt1/Nrf2/GPX4途径抑制巨噬细胞铁死亡和改善脂质代谢来减轻动脉粥样硬化。
FASEB J. 2025 Aug 15;39(15):e70917. doi: 10.1096/fj.202501047RR.
6
Epigallocatechin-3-gallate protects against osteoarthritis-induced chondrocytes dysfunction by regulating PLa2g2a.表没食子儿茶素-3-没食子酸酯通过调节PLa2g2a来预防骨关节炎诱导的软骨细胞功能障碍。
Front Pharmacol. 2025 Aug 13;16:1624818. doi: 10.3389/fphar.2025.1624818. eCollection 2025.
7
Small extracellular vesicles derived from mesenchymal stromal cells loaded with β-nicotinamide mononucleotide activate NAD/SIRT3 signaling pathway-mediated mitochondrial autophagy to delay skin aging.装载有β-烟酰胺单核苷酸的间充质基质细胞衍生的小细胞外囊泡激活NAD/SIRT3信号通路介导的线粒体自噬以延缓皮肤衰老。
Stem Cell Res Ther. 2025 Jul 1;16(1):339. doi: 10.1186/s13287-025-04460-w.
8
In vitro anticancer effect of epigallocatechin gallate nano-emulsion on head and neck cancers.表没食子儿茶素没食子酸酯纳米乳对头颈部癌的体外抗癌作用
Clin Transl Oncol. 2025 Apr 12. doi: 10.1007/s12094-025-03886-1.
9
Prescription of Controlled Substances: Benefits and Risks管制药品的处方：益处与风险
10
Effect and Mechanism of Whey Protein Isolate-Epigallocatechin Gallate Non-Covalent Complex on Skeletal Muscle Attenuation in Aging Mice.乳清分离蛋白-表没食子儿茶素没食子酸酯非共价复合物对衰老小鼠骨骼肌衰减的影响及机制
J Food Sci. 2025 Aug;90(8):e70485. doi: 10.1111/1750-3841.70485.

本文引用的文献

1
Icariin attenuates oxidative stress via SIRT1/PGC-1α pathway in SAH mice.淫羊藿苷通过SIRT1/PGC-1α通路减轻蛛网膜下腔出血小鼠的氧化应激。
Exp Neurol. 2025 Aug;390:115303. doi: 10.1016/j.expneurol.2025.115303. Epub 2025 May 8.
2
The microglial state transition as a novel mechanism by which fresh Baihe Dihuang decoction prevents depression by regulating SIRT1/HMGB1 signaling.小胶质细胞状态转变作为鲜百合地黄汤通过调节SIRT1/HMGB1信号通路预防抑郁症的新机制。
Phytomedicine. 2025 Jun;141:156718. doi: 10.1016/j.phymed.2025.156718. Epub 2025 Apr 1.
3
Wearable equipment-based telemedical management via multiparameter monitoring on cardiovascular outcomes in elderly patients with chronic coronary heart disease: an open-labelled, randomised, controlled trial.
基于可穿戴设备的远程医疗管理对老年慢性冠心病患者心血管结局的多参数监测：一项开放标签、随机对照试验。
BMJ Health Care Inform. 2024 Dec 10;31(1):e101135. doi: 10.1136/bmjhci-2024-101135.
4
The Implications of Aging on Vascular Health.衰老对血管健康的影响。
Int J Mol Sci. 2024 Oct 17;25(20):11188. doi: 10.3390/ijms252011188.
5
Drug-Loaded Mesoporous Polydopamine Nanoparticles in Chitosan Hydrogels Enable Myocardial Infarction Repair through ROS Scavenging and Inhibition of Apoptosis.载药介孔聚多巴胺纳米粒子壳聚糖水凝胶通过清除 ROS 和抑制细胞凋亡促进心肌梗死修复。
ACS Appl Mater Interfaces. 2024 Nov 13;16(45):61551-61564. doi: 10.1021/acsami.4c08155. Epub 2024 Sep 30.
6
Isopropyl 3-(3,4-Dihydroxyphenyl)-2-hydroxypropanoate Alleviates Palmitic Acid-Induced Vascular Aging in HUVEC Cells through ROS/Ferroptosis Pathway.3-(3,4-二羟基苯基)-2-羟基丙基异丁酸酯通过 ROS/铁死亡途径缓解棕榈酸诱导的 HUVEC 细胞血管衰老。
Int J Mol Sci. 2024 Aug 27;25(17):9278. doi: 10.3390/ijms25179278.
7
The Multifaceted Role of Endothelial Sirt1 in Vascular Aging: An Update.内皮 Sirt1 在血管衰老中的多效作用：最新研究进展。
Cells. 2024 Sep 1;13(17):1469. doi: 10.3390/cells13171469.
8
Inhibition of the RXRA-PPARα-FABP4 signaling pathway alleviates vascular cellular aging by an SGLT2 inhibitor in an atherosclerotic mice model.在动脉粥样硬化小鼠模型中，SGLT2抑制剂通过抑制RXRA-PPARα-FABP4信号通路减轻血管细胞衰老。
Sci China Life Sci. 2024 Dec;67(12):2678-2691. doi: 10.1007/s11427-024-2602-7. Epub 2024 Aug 29.
9
Canagliflozin Inhibits Palmitic Acid-Induced Vascular Cell Aging In Vitro through ROS/ERK and Ferroptosis Pathways.卡格列净通过ROS/ERK和铁死亡途径在体外抑制棕榈酸诱导的血管细胞衰老。
Antioxidants (Basel). 2024 Jul 11;13(7):831. doi: 10.3390/antiox13070831.
10
Ischemic cardio-cerebrovascular disease and all-cause mortality in Chinese elderly patients: a propensity-score matching study.中国老年患者缺血性心脑血管疾病和全因死亡率：倾向评分匹配研究。
Eur J Med Res. 2024 Jun 15;29(1):330. doi: 10.1186/s40001-024-01929-x.