通过SCAN-B队列分析乳腺癌中mRNA修饰机制的改变。

Analysis of the mRNA modification machinery alterations in breast cancer through the SCAN-B cohort.

作者信息

Peula Carlos, Esteva-Socias Margalida, Kumari Kanchan, Dassi Erik, Aguilo Francesca

机构信息

Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy.

Department of Molecular Biology, Umeå University, 901 87 Umeå, Sweden.

出版信息

NAR Cancer. 2025 Sep 3;7(3):zcaf027. doi: 10.1093/narcan/zcaf027. eCollection 2025 Sep.

DOI:10.1093/narcan/zcaf027

PMID:40918643

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12409412/

Abstract

Epitranscriptomic modifications regulate gene expression and have been implicated in cancer, including breast cancer. Using the SCAN-B cohort, we analyzed 49 messenger RNA modification regulators (mRMPs) across breast cancer subtypes. In the basal subtype, we found significant overexpression of mA readers (IGF2BP1-3), mC regulators (NSUN5, ALYREF, YBX1, YBX2), pseudouridine [PUS1, MARS (or MetRS), RPUSD2], and RNA editing enzymes [APOBEC3A (A3A), A3G, ADAR1], all linked to poor survival. Conversely, the mA writer METTL14 was downregulated. Our findings highlight key mRMPs as potential biomarkers and therapeutic targets, underscoring the role of RNA modifications in breast cancer progression.

摘要

表观转录组修饰可调节基因表达，并与包括乳腺癌在内的多种癌症相关。利用SCAN-B队列，我们分析了乳腺癌各亚型中的49种信使核糖核酸修饰调节因子（mRMPs）。在基底亚型中，我们发现mA阅读器（IGF2BP1 - 3）、mC调节因子（NSUN5、ALYREF、YBX1、YBX2）、假尿苷[PUS1、MARS（或MetRS）、RPUSD2]以及RNA编辑酶[APOBEC3A（A3A）、A3G、ADAR1]均显著过表达，所有这些都与较差的生存率相关。相反，mA写入器METTL14表达下调。我们的研究结果突出了关键mRMPs作为潜在生物标志物和治疗靶点的作用，强调了RNA修饰在乳腺癌进展中的作用。