Beynen A C, De Bruijne J J, Katan M B
Atherosclerosis. 1985 Dec;58(1-3):149-57. doi: 10.1016/0021-9150(85)90062-0.
Groups of 10 female Wistar rats (aged 4 weeks) were fed for 29 days either a low-cholesterol commercial diet, a commercial diet containing 2% (w/w) cholesterol, 0.5% cholate and 5% olive oil or a diet containing 2% cholestyramine. The rats were then fed the low-cholesterol commercial diet for the next 91 days and the high-cholesterol diet for another 29 days. There was no significant difference between the groups in the increase of cholesterol in serum and liver during the last period of cholesterol feeding. A fourth group of 10 animals was fed the diet containing cholesterol and cholate during the entire experimental period of 149 days. By the end of the experiment serum cholesterol in these animals was lower and liver cholesterol was higher than in the 3 groups fed the high-cholesterol diet during days 120-149 of the experiment. This study does not present evidence for imprinting effects of early diet manipulation on the later cholesterolemic response to a high cholesterol diet.
将10只4周龄的雌性Wistar大鼠分为几组，分别喂食低胆固醇商业饮食、含2%（w/w）胆固醇、0.5%胆酸盐和5%橄榄油的商业饮食或含2%消胆胺的饮食，持续29天。然后，这些大鼠在接下来的91天里喂食低胆固醇商业饮食，再在接下来的29天里喂食高胆固醇饮食。在胆固醇喂养的最后阶段，各实验组血清和肝脏中胆固醇的增加量没有显著差异。第四组10只动物在整个149天的实验期内喂食含胆固醇和胆酸盐的饮食。到实验结束时，这些动物的血清胆固醇低于实验第120 - 149天喂食高胆固醇饮食的3组动物，而肝脏胆固醇则高于这3组动物。本研究没有提供早期饮食干预对后期高胆固醇饮食胆固醇血症反应的印记效应的证据。
