Parker Remi T, Jimenez Julissa A, Huynh Thy, Brodell Robert T
Pediatrics, University of Tennessee Health Science Center, Memphis, USA.
Dermatology, University of Mississippi Medical Center, Jackson, USA.
Cureus. 2025 Aug 6;17(8):e89489. doi: 10.7759/cureus.89489. eCollection 2025 Aug.
Molluscum contagiosum (MC) is a common cutaneous viral infection predominantly affecting children. In this report, we present the case of a five-year-old male with recurrent MC who developed the beginning of the end (BOTE) sign, reflecting an inflammatory response that correlates with imminent lesion resolution. The patient's lesions were monitored without further intervention following the appearance of the BOTE sign, and complete resolution was documented in roughly two months. Serial photographs taken by the patient's parent provided visual documentation of the natural disease progression and healing of the lesions. Our case underscores the importance of distinguishing the BOTE sign from secondary bacterial infection and highlights its value in predicting spontaneous resolution, allowing clinicians to confidently opt for conservative management.
传染性软疣（MC）是一种常见的皮肤病毒感染，主要影响儿童。在本报告中，我们介绍了一名五岁男性复发性MC患者，其出现了疾病终末期起始（BOTE）体征，这反映了一种与病变即将消退相关的炎症反应。在BOTE体征出现后，对患者的病变进行了监测，未进行进一步干预，大约两个月后记录到病变完全消退。患者家长拍摄的系列照片提供了病变自然病程和愈合的视觉记录。我们的病例强调了将BOTE体征与继发性细菌感染相区分的重要性，并突出了其在预测自发消退方面的价值，使临床医生能够自信地选择保守治疗。
