Jlali Maamer, Hincelin Clémentine, Manceaux Celsa, Ozbek Sarper
Adisseo France S.A.S., European Laboratory of Innovation, Science and Expertise, Saint-Fons, France.
Adisseo France S.A.S., Antony, France.
Front Vet Sci. 2025 Aug 22;12:1591214. doi: 10.3389/fvets.2025.1591214. eCollection 2025.
Two studies were carried out to investigate the effects of a novel bacterial biosynthetic 6-phytase on growth performance, bone mineralization, and apparent total digestibility (ATTD) of phosphorus (P) in weaned piglets and growing pigs. They were carried out on 192 weaned piglets with initial body weight (BW): 9.3 ± 1.2 kg (33 days of age) and 360 growing pigs with initial BW: 33.3 ± 4.9 kg (85 days) for 43 and 84 days, respectively, according to a randomized complete block design with three treatments. The treatments were a positive control (PC) diet formulated to meet nutrient requirements, a negative control (NC) diet reduced similarly in calcium (Ca) and digestible P by 0.12% points in piglets and by 0.14, 0.11, and 0.10% points, respectively, in phases 1, 2, and 3 in growing pigs, compared to the PC diet; and the NC diet supplemented with the new 6-phytase at 500 phytase units (FTU) per kg of diet (PHY). The mineral depletion decreased final BW (-6.3%, = 0.005; -3.0%, < 0.05), average daily gain (ADG: -8.8%, = 0.003; -4.3%, < 0.05), bone ash content (-24.7%, < -9.6%, = 0.005), bone P content (-24.6%, < 0.001; -6.5%, = 0.11), and ATTD of P (-11.8% points, < 0.001; -9.2% points, < 0.001) and increased the feed-to-gain (F:G) ratio (+2.1%, < 0.001; +4.7%, < 0.05) in weaned piglets and growing pigs, respectively. Compared to animals fed the NC diet, phytase addition improved the final BW (+6.5%, = 0.006, +2.3%, < 0.05), ADG (+9.0%, = 0.005, +3.4%, < 0.05), F:G ratio (-3.1%, < 0.001, -2.4%, < 0.05), metacarpal ash content (+27.6%, < 0.001, +9.3%, = 0.004), and metacarpal P content (+29.3%, < 0.001, +7.0%, = 0.06) in weaned piglets and growing pigs, respectively. The final BW, ADG, and bone ash content in animals fed the NC diet supplemented with phytase were comparable to animals fed the PC diet. The supplementation of phytase to the NC diet improved (P < 0.001) the ATTD of P by 13.5 and 24.6% points ( < 0.001) in weaned piglets and growing pigs, respectively. Compared to the NC diet, phytase supplementation also improved the ATTD of Ca (+7.8% points, p) and N (+2.5% points) in growing pigs. This finding indicates the ability of this novel biosynthetic bacterial 6-phytase to restore performance and bone mineralization in piglets and growing pigs fed P- and Ca-reduced diets.
开展了两项研究，以调查一种新型细菌生物合成6-植酸酶对断奶仔猪和生长猪生长性能、骨矿化及磷（P）的表观总消化率（ATTD）的影响。研究分别以192头初始体重（BW）为9.3±1.2千克（33日龄）的断奶仔猪和360头初始BW为33.3±4.9千克（85日龄）的生长猪进行，为期43天和84天，采用随机完全区组设计，设三种处理。处理包括：一种按营养需求配制的正对照（PC）日粮；一种负对照（NC）日粮，与PC日粮相比，断奶仔猪日粮中钙（Ca）和可消化磷降低0.12个百分点，生长猪在第1、2、3阶段分别降低0.14、0.11和0.10个百分点；以及在NC日粮中每千克日粮添加500植酸酶单位（FTU）的新型6-植酸酶（PHY）。矿物质缺乏分别降低了断奶仔猪和生长猪的末重（-6.3%，P = 0.005；-3.0%，P < 0.05）、平均日增重（ADG：-8.8%，P = 0.003；-4.3%，P < 0.05）、骨灰含量（-24.7%；<-9.6%，P = 0.005）、骨P含量（-24.6%，P < 0.001；-6.5%，P = 0.11）以及P的ATTD（-11.8个百分点，P < 0.001；-9.2个百分点，P < 0.001），并分别提高了断奶仔猪和生长猪的料重比（F:G）（+2.1%，P < 0.001；+4.7%，P < 0.05）。与饲喂NC日粮的动物相比，添加植酸酶提高了断奶仔猪和生长猪的末重（+6.5%，P = 0.006；+2.3%，P < 0.05）、ADG（+9.0%，P = 0.005；+3.4%，P < 0.05）以及F:G比（-3.1%，P < 0.001；-2.4%，P < 0.05），并分别提高了掌骨骨灰含量（+27.6%，P < 0.001；+9.3%，P = 0.004）和掌骨P含量（+
