Dundar Ahmet, Irmak Halit, Ayhanci Tugba, Cetik Yildiz Songul
Department of Medical Services and Techniques, Health Services Vocational School, Mardin Artuklu University, Mardin, Turkiye.
Department of Computer Sciences, Mardin Artuklu University, Mardin, Turkiye.
Int J Gen Med. 2025 Sep 1;18:5039-5046. doi: 10.2147/IJGM.S544766. eCollection 2025.
Brucellosis is a zoonotic and multisystemic disease that is widespread worldwide and can present with many different clinical conditions, ranging from asymptomatic to serious and fatal conditions. Brucellosis may be linked to renal tubular and acute kidney damage, nephrotic syndrome, and various types of nephropathies.
Our research was carried out prospectively to investigate the relationship between brucellosis and various biochemical markers and particularly to investigate the role of renal tubular damage biomarkers.
Demographic and biochemical data from 60 controls and 60 brucellosis patients were included in the study. Kidney injury molecule-1 (KIM-1) and Neutrophil gelatinase-associated lipocalin (NGAL) were analyzed by. The diagnostic accuracy of KIM-1 and NGAL for brucellosis was assessed using receiver operating characteristic (ROC) curve analysis.
According to our findings, significant differences of KIM-1 and NGAL were observed between brucellosis and healthy patients. A high AUC (area under the curve) value of 0.742 (95% CI: 0.616-0.868) and 0.835 (95% CI: 0.729-0.941) was observed for KIM-1 and NGAL, respectively.
Serum levels of KIM-1 and NGAL, which are renal tubular damage markers, where higher in Brucellosis than in healthy patients. These biomarkers can contribute to the rapid and accurate diagnosis of brucellosis regarding the involvement of nephropathies and to the standardization of comprehensive diagnostic warning indicators.
布鲁氏菌病是一种人畜共患的多系统疾病，在全球广泛传播，可呈现多种不同的临床症状，从无症状到严重及致命情况不等。布鲁氏菌病可能与肾小管及急性肾损伤、肾病综合征和各种类型的肾病有关。
我们进行了前瞻性研究，以调查布鲁氏菌病与各种生化标志物之间的关系，特别是研究肾小管损伤生物标志物的作用。
本研究纳入了60名对照者和60名布鲁氏菌病患者的人口统计学和生化数据。通过分析肾损伤分子-1（KIM-1）和中性粒细胞明胶酶相关脂质运载蛋白（NGAL）。使用受试者工作特征（ROC）曲线分析评估KIM-1和NGAL对布鲁氏菌病的诊断准确性。
根据我们的研究结果，在布鲁氏菌病患者和健康患者之间观察到KIM-1和NGAL存在显著差异。KIM-1和NGAL的曲线下面积（AUC）值分别为0.742（95%CI：0.616-0.868）和0.835（95%CI：0.729-0.941）。
作为肾小管损伤标志物的KIM-1和NGAL血清水平在布鲁氏菌病患者中高于健康患者。这些生物标志物有助于快速准确地诊断布鲁氏菌病是否累及肾病，并有助于综合诊断警示指标的标准化。
