Huang Yihan, Jiang Jiaying, Jiang Kui, Wang Bangmao, Liu Tianyu, Cao Hailong
Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, National Key Clinical Specialty, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China.
Front Oncol. 2025 Aug 21;15:1544858. doi: 10.3389/fonc.2025.1544858. eCollection 2025.
Mucosa-associated lymphoid tissue (MALT) lymphoma of the small intestine is relatively rare, and the treatment guideline has not been established yet. Here we present a case of MALT lymphoma in the terminal ileum, which regressed after () eradication. A 53-year-old man had complained of abdominal discomfort and underwent a gastrointestinal endoscopic examination. -associated erosive gastritis was diagnosed, and superficial ulcerated lesions were also found in the terminal ileum. Histopathologic examination and immunohistochemical analyses of ileal biopsy specimens confirmed the diagnosis of MALT lymphoma. No distant lymph node metastasis or other organ involvement was detected in positron emission tomography/computed tomography. Surprisingly, the ileum reached mucosal healing after quadruple therapy regimens for eradication without additional treatments. There were no signs of recurrence during the follow-up for 18 months. The unique case which located only in the ileum revealed that eradication of might be an effective treatment and deserves further studies. Moreover, we also provide a detailed overview of recently published literature regarding the eradication treatment for intestinal MALT lymphoma.
小肠黏膜相关淋巴组织（MALT）淋巴瘤相对罕见，目前尚未建立治疗指南。在此，我们报告一例回肠末端的MALT淋巴瘤病例，该病例在（）根除后病情缓解。一名53岁男性主诉腹部不适，接受了胃肠内镜检查。诊断为（）相关性糜烂性胃炎，同时在回肠末端也发现了浅表溃疡病变。回肠活检标本的组织病理学检查和免疫组化分析确诊为MALT淋巴瘤。正电子发射断层扫描/计算机断层扫描未发现远处淋巴结转移或其他器官受累。令人惊讶的是，在进行根除（）的四联疗法后，回肠达到黏膜愈合，无需额外治疗。在18个月的随访期间没有复发迹象。这个仅位于回肠的独特病例表明，根除（）可能是一种有效的治疗方法，值得进一步研究。此外，我们还详细概述了最近发表的关于肠道MALT淋巴瘤根除治疗的文献。
