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神经毒性蛇毒致眼炎经眼部途径引起的全身中毒——病例报告

Systemic Envenomation via Ocular Route from a Neurotoxic Snake Venom Ophthalmia--A Case Report.

作者信息

Rodriguez Gerwin John D, Sabueto Christy Aleen P, Custodio Debrah Ann R, Nogas Ella Joy L

机构信息

Southern Philippines Medical Center Department of Emergency Medicine Medical Officer III Philippines.

Southern Philippines Medical Center Department of Emergency Medicine Consultant Philippines.

出版信息

J Acute Med. 2025 Sep 1;15(3):112-116. doi: 10.6705/j.jacme.202509_15(3).0005.

Abstract

Snake envenomation is a neglected tropical disease with two million snake bites reported each year (WHO). Much less common is snake venom ophthalmia secondary to eye exposure from spitting snakes. This paper reports an unusual case of systemic envenomation via the ocular route of a 14-year old male from the Philippines. A mixture of snake blood and venom came in contact with the patient's left eye causing severe pain and blurring of vision, shortly followed by generalized body weakness and ptosis. Copious irrigation with normal saline was done at the emergency room, and Purified Cobra Antivenin (PCAV) was administered. Symptoms of systemic envenomation abated following PCAV administration. Ofloxacin ophthalmic drops and eye lubrication were prescribed for seven days to minimize complications, and the patient was discharged well after three days of hospitalization. Although difficult to ascertain, signs and symptoms pointed to systemic envenomation, and this could be the first case of an unconventional venom route to date. This paper opens possibilities and serves as precedent for future research - ocular envenomation, snake venom, and blood components, and symptomatic management.

摘要

蛇咬伤是一种被忽视的热带病,世界卫生组织报告称每年有200万起蛇咬伤事件。因接触喷毒眼镜蛇眼部而继发的蛇毒致眼炎则更为罕见。本文报告了一例来自菲律宾的14岁男性通过眼部途径发生全身中毒的不寻常病例。蛇血和毒液的混合物接触到患者左眼,导致剧痛和视力模糊,随后不久出现全身无力和上睑下垂。在急诊室用大量生理盐水冲洗,并注射了精制抗眼镜蛇毒血清(PCAV)。注射PCAV后,全身中毒症状减轻。开了七天的氧氟沙星眼药水和眼部润滑剂以尽量减少并发症,患者住院三天后康复出院。尽管难以确定,但症状和体征表明发生了全身中毒,这可能是迄今为止首例非常规毒液途径的病例。本文为未来的研究——眼部中毒、蛇毒和血液成分以及症状处理开辟了可能性并提供了先例。

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