de Barbosa Bárbara Faria Sa, Ferreira Neto José Leôncio, de Oliveira Francisca Jennifer Duarte, Leitão Juliana Sales Osterno, Costa Moan Jéfter Fernandes, Sette-de-Souza Pedro Henrique, Fechine Pierre Basílio Almeida, Feitosa Victor Pinheiro, Borges Boniek Castillo Dutra
Department of Dentistry, Universidade Federal do Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil.
Group of Chemistry of Advanced Materials (GQMat), Department of Analytical Chemistry and Physical Chemistry, Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil.
Clin Exp Dent Res. 2025 Oct;11(5):e70219. doi: 10.1002/cre2.70219.
Through a scoping review, this study meticulously mapped and characterized these nanostructured clays used to release antibacterial active compounds from direct restorative dental materials.
The systematic approach involved searches in the PubMed/MEDLINE, Lilacs, Web of Science, Scopus, ScienceDirect, and Embase databases. Two independent and calibrated researchers (kappa: 0.94) performed all systematic steps according to the PRISMA guideline and the Joanna Briggs Institute Scoping Review Methodology Group (JBI) protocol. The reviewers developed a data extraction table to gather key information.
A total of 782 articles were retrieved in the initial search using the specified strategies. After thoroughly reviewing the manuscripts, five were selected following the exclusion of duplicates and application of eligibility criteria. Montmorillonite and halloysite nanotubes emerged as the predominant nanostructured clay. Cetylpyridinium chloride was the most common active agent, notable for its antibacterial properties. Resin-based composites were the most frequently studied direct restorative material for the prevention of recurrent caries.
Although the number of primary studies published in the literature was limited, montmorillonite and halloysite nanotubes appear to be promising nanocarriers for antibacterial active compounds in direct restorative dental materials.
通过范围综述，本研究精心绘制并描述了用于从牙科直接修复材料中释放抗菌活性化合物的这些纳米结构粘土。
系统方法包括在PubMed/MEDLINE、Lilacs、科学网、Scopus、ScienceDirect和Embase数据库中进行检索。两名独立且经过校准的研究人员（kappa值：0.94）根据PRISMA指南和乔安娜·布里格斯研究所范围综述方法学小组（JBI）方案执行所有系统步骤。评审人员制定了一个数据提取表来收集关键信息。
使用指定策略进行初步检索共检索到782篇文章。在对稿件进行全面评审后，排除重复项并应用纳入标准后，选择了5篇文章。蒙脱石和埃洛石纳米管是主要的纳米结构粘土。十六烷基氯化吡啶是最常见的活性剂，以其抗菌性能而闻名。树脂基复合材料是预防继发龋最常研究的直接修复材料。
尽管文献中发表的原始研究数量有限，但蒙脱石和埃洛石纳米管似乎是牙科直接修复材料中抗菌活性化合物的有前景的纳米载体。
