[2-氯-1-甲基碘化吡啶鎓。一种适用于肽合成的试剂]
[2-Chloro-1-methylpyridinium iodide. A suitable reagent for peptide synthesis].
作者信息
Keese W, Khalaf H, Grambow D, Grundke G, Rimpler M
出版信息
Biol Chem Hoppe Seyler. 1985 Dec;366(12):1093-5.
PMID:4091968
Abstract
2-Chloro-1-methylpyridinium iodide is a coupling reagent for peptide synthesis. By its use different peptides were synthesized with protected di- and trifunctional amino acids. While urethan-protected amino acids react free of racemization, the fragment condensation needs N-Hydroxysuccinimide, as shown by the Young test.
摘要
2-氯-1-甲基碘化吡啶鎓是一种用于肽合成的偶联试剂。使用该试剂可与受保护的双官能和三官能氨基酸合成不同的肽。虽然氨基甲酸酯保护的氨基酸在反应时不会发生消旋，但片段缩合需要N-羟基琥珀酰亚胺，这在扬氏试验中得到了证实。
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