Albayrak Muzaffer Talha, Kasım Burcu, Çiloğlu Emine, Turan Miray Faiz, Koçluk Yusuf
Department of Ophthalmology, Kayseri State Hospital, Kayseri, Turkey.
Department of Ophthalmology, Adana City Training and Research Hospital, Adana, Turkey.
Cell Tissue Bank. 2025 Sep 8;26(3):42. doi: 10.1007/s10561-025-10192-1.
To evaluate long‑term outcomes of corneal patch grafting (CPG) and to determine prognostic factors for anatomical and functional success. This retrospective study included 35 eyes from 35 patients who underwent CPG between April 2016 and September 2022 at Adana City Training and Research Hospital. Collected data included age, sex, preoperative and postoperative best-corrected visual acuity (BCVA), graft localization and size, anterior segment findings, graft survival, secondary surgical procedures, and rates of anatomical and functional success. Anatomical success was achieved in 82.9% (29/35), and functional success in 45.7% (16/35). The most common reason for CPG was non-infectious, non-traumatic perforation related to immune disorders (37.1%). Anatomical success was not significantly associated with the primary etiology (p = 0.73), whereas functional success was significantly higher in patients with traumatic corneal perforations (p = 0.029). A statistically significant improvement was observed in postoperative BCVA for the study group (p < 0.001). Functional success was significantly associated with younger age and peripheral graft location (p = 0.005 and p < 0.001, respectively). Smaller graft diameter was significantly correlated with both higher anatomical and functional success (p = 0.031 and p = 0.007, respectively), while no significant association was found with horizontal graft diameter (p = 0.27 and p = 0.068, respectively). Corneal patch grafting is a highly effective technique for restoring anatomical integrity in most patients and provides acceptable functional outcomes in selected cases. Younger age, peripheral graft location, and smaller graft diameter appear to be favorable prognostic factors for functional recovery.
评估角膜补片移植（CPG）的长期效果，并确定解剖学和功能成功的预后因素。这项回顾性研究纳入了2016年4月至2022年9月在阿达纳市培训和研究医院接受CPG的35例患者的35只眼睛。收集的数据包括年龄、性别、术前和术后最佳矫正视力（BCVA）、移植片的位置和大小、眼前段检查结果、移植片存活情况、二次手术操作以及解剖学和功能成功的发生率。解剖学成功的比例为82.9%（29/35），功能成功的比例为45.7%（16/35）。CPG最常见的原因是与免疫紊乱相关的非感染性、非创伤性穿孔（37.1%）。解剖学成功与原发性病因无显著相关性（p = 0.73），而创伤性角膜穿孔患者的功能成功率显著更高（p = 0.029）。研究组术后BCVA有统计学意义的改善（p < 0.001）。功能成功与年龄较小和移植片位于周边显著相关（分别为p = 0.005和p < 0.001）。较小的移植片直径与更高的解剖学和功能成功率均显著相关（分别为p = 0.031和p = 0.007），而与移植片水平直径无显著相关性（分别为p = 0.27和p = 0.068）。角膜补片移植是一种在大多数患者中恢复解剖完整性的高效技术，在某些情况下可提供可接受的功能结果。年龄较小、移植片位于周边和较小的移植片直径似乎是功能恢复的有利预后因素。
